Traditional Chinese medicine for post-viral olfactory dysfunction: A systematic review

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research Pub Date : 2024-04-25 DOI:10.1016/j.imr.2024.101045

Xiang-yun Zou , Xue-han Liu , Chun-li Lu , Xin-yan Jin , Bai-xiang He , Yi-lei Liao , Ting Liu , Yi-dan Dai , Shi-hao Qi , Zhu-jun Sheng , Zhan-feng Yan , Guo-Yan Yang , Trine Stub , Jian-ping Liu

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引用次数: 0

Abstract

Background

Post-viral olfactory dysfunction (PVOD) is the common symptoms of long COVID, lacking of effective treatments. Traditional Chinese medicine (TCM) is claimed to be effective in treating olfactory dysfunction, but the evidence has not yet been critically appraised. We conducted a systematic review to evaluate the effectiveness and safety of TCM for PVOD.

Methods

We searched eight databases to identified clinical controlled studies about TCM for PVOD. The Cochrane risk of bias tools and GRADE were used to evaluate the quality of evidence. Risk ratio (RR), mean differences (MD), and 95 % confidence interval (CI), were used for effect estimation and RevMan 5.4.1 was used for data analysis.

Results

Six randomized controlled trials (RCTs) (545 participants), two non-randomized controlled trials (non-RCTs) (112 participants), and one retrospective cohort study (30 participants) were included. The overall quality of included studies was low. Acupuncture (n = 8) and acupoint injection (n = 3) were the mainly used TCM therapies. Five RCTs showed a better effect in TCM group. Four trials used acupuncture, and three trials used acupoint injection. The results of two non-RCTs and one cohort study were not statistically significant. Two trials reported mild to moderate adverse events (pain and brief syncope caused by acupuncture or acupoint injection).

Conclusions

Limited evidence focus on acupuncture and acupoint injection for PVOD and suggests that acupuncture and acupoint injection may be effective in improving PVOD. More well-designed trials should focus on acupuncture to confirm the benefit.

Protocol registration

The protocol of this review was registered at PROSPERO: CRD42022366776.

查看原文本刊更多论文

中药治疗病毒后嗅觉功能障碍：系统综述

背景病毒后嗅觉障碍（PVOD）是长期感染 COVID 后的常见症状，缺乏有效的治疗方法。传统中医（TCM）被认为能有效治疗嗅觉障碍，但尚未对相关证据进行严格评估。我们进行了一项系统性综述，以评估中医药治疗嗅觉障碍的有效性和安全性。方法我们检索了八个数据库，以确定有关中医药治疗嗅觉障碍的临床对照研究。采用 Cochrane 偏倚风险工具和 GRADE 评估证据质量。结果纳入了 6 项随机对照试验（RCTs）（545 名参与者）、2 项非随机对照试验（non-RCTs）（112 名参与者）和 1 项回顾性队列研究（30 名参与者）。纳入研究的总体质量较低。针灸（8 项）和穴位注射（3 项）是主要的中医疗法。5 项研究表明，中医组的疗效更好。四项试验采用针灸，三项试验采用穴位注射。两项非研究性对比试验和一项队列研究的结果无统计学意义。有两项试验报告了轻度至中度的不良反应（针灸或穴位注射引起的疼痛和短暂晕厥）。结论有限的证据集中于针灸和穴位注射治疗 PVOD，表明针灸和穴位注射可能对改善 PVOD 有效。更多设计良好的试验应关注针灸，以确认其益处。协议注册本综述的协议已在 PROSPERO 注册：CRD42022366776。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Integrative Medicine Research Medicine-Complementary and Alternative Medicine

CiteScore

6.50

自引率

2.90%

发文量

审稿时长

12 weeks

期刊介绍： Integrative Medicine Research (IMR) is a quarterly, peer-reviewed journal focused on scientific research for integrative medicine including traditional medicine (emphasis on acupuncture and herbal medicine), complementary and alternative medicine, and systems medicine. The journal includes papers on basic research, clinical research, methodology, theory, computational analysis and modelling, topical reviews, medical history, education and policy based on physiology, pathology, diagnosis and the systems approach in the field of integrative medicine.