ST8-t008-SCCmec IV methicillin-resistant Staphylococcus aureus in retail fresh cheese

JDS communications Pub Date : 2024-11-01 DOI:10.3168/jdsc.2023-0521

Carolina Chaves , Melissa Montenegro , Hyrina Piedra , Marta Pérez-Villanueva , César Rodríguez

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Abstract

This study reports the finding of 3 ST8-t008-SCC_mec IVa (2B) methicillin-resistant Staphylococcus aureus (MRSA) strains in fresh cheese purchased within a single market in Costa Rica. In line with the finding of the resistance genes mecA, blaZ, mph(C), and msr(A) in their genomes, these bacteria showed phenotypic resistance to multiple β-lactams and erythromycin. In addition, they carry genes for acquired resistance to aminoglycosides (aph(3′)-III) and fosfomycin (fosD), and genes for a myriad of virulence factors, including adhesins, hemolysins, and exotoxins. Our strains share multiple genomic features with MRSA from the USA300 lineage, which is a widely distributed and highly virulent strain implicated in community infections. As a result, consuming these or similar products could lead to multidrug infections in susceptible individuals. These results highlight safety deficiencies in cheese production practices and emphasize the risk of foodborne transmission of hard-to-treat ST8 MRSA strains.

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零售新鲜奶酪中的 ST8-t008-SCC IV 型耐甲氧西林金黄色葡萄球菌（MRSA）

本研究报告称，在哥斯达黎加一个市场上购买的新鲜奶酪中发现了 3 株 ST8-t008-SCCmec IVa (2B) 耐甲氧西林金黄色葡萄球菌（MRSA）。由于在其基因组中发现了耐药基因 mecA、blaZ、mph(C) 和 msr(A)，这些细菌表现出对多种 β-内酰胺类药物和红霉素的表型耐药性。此外，它们还携带对氨基糖苷类（aph(3′)-III）和磷霉素（fosD）的获得性抗性基因，以及大量毒力因子的基因，包括粘附素、溶血素和外毒素。我们的菌株与美国 300 株系的 MRSA 有多个基因组特征，后者是一种广泛分布的高致病性菌株，与社区感染有牵连。因此，食用这些产品或类似产品可能会导致易感人群感染多种药物。这些结果凸显了奶酪生产实践中的安全缺陷，并强调了难以处理的 ST8 MRSA 菌株通过食物传播的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

JDS communications Animal Science and Zoology

CiteScore

2.00

自引率

0.00%

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