Association of breast cancer with quantitative mammographic density measures for women receiving contrast-enhanced mammography.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-04-02 DOI:10.1093/jncics/pkae026

Gordon P. Watt, Krishna N Keshavamurthy, T. Nguyen, M. Lobbes, M. Jochelson, Janice S. Sung, C. Moskowitz, Prusha Patel, Xiaolin Liang, Meghan Woods, John L. Hopper, M. C. Pike, J. Bernstein

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Abstract

Women with high mammographic density (MD) have an increased risk of breast cancer. They may be offered contrast-enhanced mammogram (CEM) to improve breast cancer screening performance. Using a cohort of women receiving CEM, we evaluated whether conventional and modified MD measures were associated with breast cancer. Sixty-six cases with newly diagnosed unilateral breast cancer were frequency-matched on age to 133 cancer-free controls. On low-energy cranio-caudal CEMs (equivalent to standard mammogram), we measured quantitative MD using CUMULUS software at the conventional intensity threshold ("Cumulus") and higher-than-conventional thresholds ("Altocumulus", "Cirrocumulus"). The measures were standardized to enable estimation of odds per age- and adiposity-adjusted standard deviation (OPERA). In multivariable logistic regression of case-control status, only the highest-intensity measure, Cirrocumulus, was statistically significantly associated with breast cancer (OPERA = 1.40, 95% CI 1.04-1.89). Conventional Cumulus did not contribute to model fit. For women receiving CEM, Cirrocumulus MD might better predict breast cancer than conventional quantitative MD.

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接受对比增强乳腺 X 射线照相术的妇女患乳腺癌与乳腺 X 射线密度定量测量的关系。

乳房 X 线照相密度（MD）高的女性患乳腺癌的风险更高。为了提高乳腺癌筛查效果，她们可能会接受造影剂增强乳腺 X 线照相术（CEM）。我们利用一组接受 CEM 检查的妇女，评估了传统和改良的 MD 测量值是否与乳腺癌有关。将 66 例新确诊的单侧乳腺癌病例与 133 例未患癌症的对照组进行年龄频率匹配。我们使用 CUMULUS 软件在常规强度阈值（"Cumulus"）和高于常规强度阈值（"Altocumulus"、"Cirrocumulus"）下对低能量头颈部 CEM（相当于标准乳房 X 光检查）进行定量 MD 测量。对测量结果进行了标准化处理，以便估算出每年龄和脂肪调整标准偏差（OPERA）的几率。在病例对照状态的多变量逻辑回归中，只有强度最高的测量值 "Cirrocumulus "与乳腺癌有显著的统计学关联（OPERA = 1.40，95% CI 1.04-1.89）。常规积云对模型拟合无贡献。对于接受 CEM 治疗的妇女，Cirrocumulus MD 可能比传统的定量 MD 更能预测乳腺癌。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567

期刊介绍： ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric. Indexed/Abstracted： Web of Science SCIE Scopus CAS INSPEC Portico