Pro- and Anti-inflammatory Biomarkers Responses after Aerobic Training in Heart Transplant Recipients: A Systematic Review and Meta-analysis.

IF 2.4 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Cardiology Reviews Pub Date : 2024-04-02 DOI:10.2174/011573403X269909240320061952

L. Franzoni, Stephanie Bastos da Motta, Gabriel Carvalho, Rochelle Rocha Costa, M. M. Ahner, M. Saffi, A. A. Pereira, A. H. Pereira, A. D. da Silveira, Ricardo Stein

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引用次数: 0

Abstract

BACKGROUND Physical exercise (PE) may improve plasma concentration of interleukin- 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and adiponectin (adpN) in heart transplant (HT) patients. However, no consistent data is available on this population. AIM Thus, we aimed to conduct a systematic review and meta-analysis on the effects of PE over these pro- and anti-inflammatory biomarkers in HT patients. METHODS Following the guidelines established by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement, we conducted a systematic literature search in the PubMed, Cochrane, and Scopus databases. Outcomes included IL-6, TNF-alpha, and adpN. Effect size (ES) was calculated using the standardized mean difference with a 95% confidence interval (CI). RESULTS The PE group (aerobic modality) was associated with reduced IL-6 compared to the control group (ES: -0.53; 95% CI: -0.99 to -0.06 pg/mL; P = 0.026). However, the PE group did not show a significant effect on TNF-alpha and adpN levels (ES: -0.33; 95% CI: -0.79 to 0.13; P = 0.16 and ES: -0.20; 95% CI: -0.70 to 0.30 pg/mL; P = 0.444, respectively). CONCLUSION PE is associated with IL-6 reductions, although TNF alpha and adpN did not change after this intervention in HT patients. Therefore, PE is an effective intervention to downregulate IL-6 in post-HT patients.

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心脏移植受者有氧训练后的促炎和抗炎生物标志物反应：系统回顾与元分析》。

背景体育锻炼（PE）可改善心脏移植（HT）患者血浆中白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和脂联素（adpN）的浓度。因此，我们旨在对 PE 对 HT 患者这些促炎和抗炎生物标志物的影响进行系统回顾和荟萃分析。方法按照《系统回顾和荟萃分析首选报告项目》（Preferred Reporting Items for Systematic Reviews and Meta-Analyses，PRISMA）2020 声明制定的指南，我们在 PubMed、Cochrane 和 Scopus 数据库中进行了系统的文献检索。研究结果包括 IL-6、TNF-α 和 adpN。结果与对照组相比，PE 组（有氧模式）与 IL-6 降低相关（ES：-0.53；95% CI：-0.99 至 -0.06 pg/mL；P = 0.026）。然而，PE组对TNF-α和adpN水平并无明显影响（ES：-0.33；95% CI：-0.79至0.13；P = 0.16和ES：-0.20；95% CI：-0.70至0.30 pg/mL；P = 0.444）。因此，PE 是下调 HT 后患者 IL-6 的有效干预措施。

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来源期刊

Current Cardiology Reviews CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

3.70

自引率

10.50%

发文量

117

期刊介绍： Current Cardiology Reviews publishes frontier reviews of high quality on all the latest advances on the practical and clinical approach to the diagnosis and treatment of cardiovascular disease. All relevant areas are covered by the journal including arrhythmia, congestive heart failure, cardiomyopathy, congenital heart disease, drugs, methodology, pacing, and preventive cardiology. The journal is essential reading for all researchers and clinicians in cardiology.