Elevated serum irisin levels in boys with central precocious puberty independent of BMI.

D. Zeng, Yanfei Chen, Tao Xie, Wei Qin, Qi Meng, Dan Lan
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Abstract

INTRODUCTION Central precocious puberty (CPP) is a prevalent endocrine disorder. Research has indicated that pubertal development is linked to nutritional metabolism. Irisin, a novel myokine/adipokine, has been identified as a potential predictor of CPP in girls. This study aims to examine the relationship between serum irisin levels and CPP in boys. MATERIAL AND METHODS An enzyme-linked immunosorbent assay (ELISA) was used to measure serum irisin levels in 32 boys diagnosed with CPP and 33 prepubertal age-matched boys as normal controls (NC). To assess the impact of body mass index (BMI) on irisin levels, both the CPP and NC groups were divided into overweight/obese and normal-weight subgroups. Spearman correlation analysis was employed to assess the connection between irisin and clinical and biochemical parameters. Additionally, a receiver operating characteristic curve was utilised to determine the optimal threshold value for irisin. RESULTS In the normal-weight subgroups, boys with CPP exhibited elevated irisin levels compared to controls, but not in the overweight/obese subgroups. The optimal cut-off value for irisin levels to predict CPP in the normal-weight groups was 93.09 ng/mL, yielding a sensitivity of 47.6% and a specificity of 100%. Furthermore, a positive correlation was noted between irisin levels and bone age (BA), bone age advancement (BA-CA), and BMI. CONCLUSIONS Serum irisin levels correlate with BMI and pubertal development. Given its limited sensitivity, irisin level can only be utilised as a supplementary rather than a standalone diagnostic indicator for CPP.
中枢性性早熟男孩血清鸢尾素水平升高与体重指数无关。
简介中枢性性早熟(CPP)是一种普遍存在的内分泌失调症。研究表明,青春期发育与营养代谢有关。鸢尾素是一种新型肌激酶/肾上腺素激酶,被认为是预测女孩性早熟的潜在指标。材料与方法采用酶联免疫吸附试验(ELISA)测量了32名确诊为CPP的男孩和33名青春期前年龄匹配的正常对照(NC)男孩的血清鸢尾素水平。为了评估体重指数(BMI)对鸢尾素水平的影响,CPP 组和 NC 组都被分为超重/肥胖亚组和正常体重亚组。斯皮尔曼相关分析用于评估鸢尾素与临床和生化参数之间的联系。结果 在正常体重亚组中,与对照组相比,CPP 男孩的鸢尾素水平升高,但在超重/肥胖亚组中,鸢尾素水平没有升高。在正常体重组中,预测 CPP 的最佳鸢尾素水平临界值为 93.09 纳克/毫升,灵敏度为 47.6%,特异度为 100%。结论血清鸢尾素水平与体重指数和青春期发育相关。鉴于其敏感性有限,鸢尾素水平只能作为 CPP 的辅助诊断指标,而非独立诊断指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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