L. Penubarthi, G. Upreti, Sabharisan Paramasivam, Sivaraman Ganesan, Arun Alexander, Regi Thomas
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引用次数: 0
Abstract
Objectives: Based on current evidence, this systematic review focuses on various grey areas related to these patients' diagnosis, management and follow-up in central skull base osteomyelitis (CSBO).
Study design: A systematic review of all case reports and observational studies.
Methods: We systematically searched PubMed, Scopus database, Cochrane database, UK clinicaltrails.gov registry, and WHO ICTRP and included all reports as per our inclusion criteria. Data was analyzed systematically, and we made essential observations.
Results: Out of 179 articles, 25 were selected according to inclusion criteria and quality assessment. Among the 44 patients, refractory headache (95%) was the most common presentation, followed by cranial nerve paralysis (82%) and Pseudomonas (32%) as the most common bacteria. Contrary to the available literature the disease cure was worse in those who underwent targeted biopsy (64% VS 36%, P = 0.023) and surgical debridement (61% vs 39%, P = 0.013) in the late stages of the disease.
Conclusions: Otogenic osteomyelitis can spread to central skull bones in the absence of obvious ear symptoms. Early diagnosis and intervention of CSBO before progression to late stages can help decrease significant morbidity and mortality.
期刊介绍:
The Journal of Neurological Surgery Part B: Skull Base (JNLS B) is a major publication from the world''s leading publisher in neurosurgery. JNLS B currently serves as the official organ of several national and international neurosurgery and skull base societies.
JNLS B is a peer-reviewed journal publishing original research, review articles, and technical notes covering all aspects of neurological surgery. The focus of JNLS B includes microsurgery as well as the latest minimally invasive techniques, such as stereotactic-guided surgery, endoscopy, and endovascular procedures. JNLS B is devoted to the techniques and procedures of skull base surgery.