Therapeutic Effect of Synbiotics (Lactobacillus reuteri, Lactobacillus rhamnosus, Bifidobacterium infantis, and Fructooligosaccharides (FOS)) on Acute non-Bloody Diarrheal Episodes in Hospitalized Children Aged Between 6 - 24 Months: Randomized Double-Blind Placebo-Controlled Trial

IF 1 Q4 PHARMACOLOGY & PHARMACY
Mrhran Hakimzadeh, Azadeh Arefian, M. Ahmadi, H. Javaherizadeh
{"title":"Therapeutic Effect of Synbiotics (Lactobacillus reuteri, Lactobacillus rhamnosus, Bifidobacterium infantis, and Fructooligosaccharides (FOS)) on Acute non-Bloody Diarrheal Episodes in Hospitalized Children Aged Between 6 - 24 Months: Randomized Double-Blind Placebo-Controlled Trial","authors":"Mrhran Hakimzadeh, Azadeh Arefian, M. Ahmadi, H. Javaherizadeh","doi":"10.5812/jjnpp-144123","DOIUrl":null,"url":null,"abstract":"Background: Regarding the appropriate effect of probiotics in treating acute diarrhea and the high prevalence of non-bacterial acute diarrhea among children in the population. Objectives: The present study evaluates the effect of synbiotic drops in children with acute diarrhea, including the number of hospitalization days, daily excreted diarrhea volume, duration of diarrhea, and reduction in the number of excretions between the case and control groups. Methods: This was a prospective double-blinded and randomized-controlled clinical trial on children aged 6 - 24 months with non-bloody acute diarrhea were included. The reason for hospitalization was diarrhea. In the case group, the patients consume PediLact (Zisttakhmir, Tehran, Iran) drop (Lactobacillus rhamnosus, Lactobacillus reuteri, and bifidobacterium infantis) 109 CFU and fructooligosaccharides. PediLact drop was used with milk or lukewarm food for five days along with other routine hospital cares. The number of hospitalization days, the daily excreted diarrhea, diarrhea duration, and decreasing numbers of excretion in patients were compared. Results: In the current study, 114 children were included. The duration of hospitalization was 3.87 ± 0.9 days in the synbiotic group and 4.26 ± 0.12 days in the placebo group (P-value = 0.001). The time between the onset of diarrhea and recovery was significantly higher in the placebo group than in the synbiotic group (P = 0.032). The number of evacuations was 1.89 ± 0.13 in the synbiotic group and 2.52 ± 0.18 in the placebo group (P = 0.014).","PeriodicalId":17745,"journal":{"name":"Jundishapur Journal of Natural Pharmaceutical Products","volume":null,"pages":null},"PeriodicalIF":1.0000,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Jundishapur Journal of Natural Pharmaceutical Products","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5812/jjnpp-144123","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Regarding the appropriate effect of probiotics in treating acute diarrhea and the high prevalence of non-bacterial acute diarrhea among children in the population. Objectives: The present study evaluates the effect of synbiotic drops in children with acute diarrhea, including the number of hospitalization days, daily excreted diarrhea volume, duration of diarrhea, and reduction in the number of excretions between the case and control groups. Methods: This was a prospective double-blinded and randomized-controlled clinical trial on children aged 6 - 24 months with non-bloody acute diarrhea were included. The reason for hospitalization was diarrhea. In the case group, the patients consume PediLact (Zisttakhmir, Tehran, Iran) drop (Lactobacillus rhamnosus, Lactobacillus reuteri, and bifidobacterium infantis) 109 CFU and fructooligosaccharides. PediLact drop was used with milk or lukewarm food for five days along with other routine hospital cares. The number of hospitalization days, the daily excreted diarrhea, diarrhea duration, and decreasing numbers of excretion in patients were compared. Results: In the current study, 114 children were included. The duration of hospitalization was 3.87 ± 0.9 days in the synbiotic group and 4.26 ± 0.12 days in the placebo group (P-value = 0.001). The time between the onset of diarrhea and recovery was significantly higher in the placebo group than in the synbiotic group (P = 0.032). The number of evacuations was 1.89 ± 0.13 in the synbiotic group and 2.52 ± 0.18 in the placebo group (P = 0.014).
复合益生菌(纽崔莱乳杆菌、鼠李糖乳杆菌、婴儿双歧杆菌和果寡糖 (FOS))对 6-24 个月住院儿童急性非血性腹泻发作的治疗效果:随机双盲安慰剂对照试验
背景:关于益生菌治疗急性腹泻的适当效果,以及非细菌性急性腹泻在儿童人群中的高发病率。研究目的本研究评估了合生元滴剂对急性腹泻患儿的治疗效果,包括病例组和对照组之间的住院天数、每日腹泻排泄量、腹泻持续时间以及排泄次数的减少。研究方法这是一项前瞻性双盲随机对照临床试验,研究对象为 6-24 个月大的非带血急性腹泻患儿。住院原因为腹泻。在病例组中,患者服用了 PediLact(Zisttakhmir,伊朗德黑兰)滴剂(鼠李糖乳杆菌、芦特乳杆菌和婴儿双歧杆菌)109 CFU 和果寡糖。PediLact 滴剂与牛奶或温热食物一起使用,连用五天,同时进行其他常规住院护理。比较了患者的住院天数、每日腹泻排泄量、腹泻持续时间和排泄量递减情况。结果本次研究共纳入 114 名儿童。合生元组的住院时间为 3.87 ± 0.9 天,安慰剂组为 4.26 ± 0.12 天(P 值 = 0.001)。安慰剂组从腹泻开始到恢复的时间明显高于合生元组(P = 0.032)。合生元组的排便次数为 1.89 ± 0.13,安慰剂组为 2.52 ± 0.18(P = 0.014)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
1.40
自引率
0.00%
发文量
26
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信