Impact of latent toxoplasmosis on pneumonic and non-pneumonic COVID-19 patients with estimation of relevant oxidative stress biomarkers.

IF 1.5 4区 医学 Q3 PARASITOLOGY
D. Hamdy, Ragaey A. Eid, Heba Abdel-Tawab, Mohamed A. El-Badry, Abdelrahman M Abdallah, Wegdan M. Abd El Wahab
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引用次数: 0

Abstract

Susceptibility to COVID-19, the most devastating global pandemic, appears to vary widely across different population groups. Exposure to toxoplasmosis has been proposed as a theory to explain the diversity of these populations. The aim of the present study was to investigate the possible association between latent toxoplasmosis and COVID-19 and its probable correlation with markers of oxidative stress, C-reactive protein (CRP) and ferritin. In a case-control study, blood samples were collected from 91 confirmed (48 non-pneumonic; NP, and 43 pneumonic; P) COVID-19 patients and 45 healthy controls. All participants were tested for IgG anti-Toxoplasma gondii antibodies and oxidative stress markers (nitric oxide [NO], superoxide dismutase [SOD] and reduced glutathione [GSH]), and CRP and serum ferritin levels were determined. In COVID-19 patients, IgG anti-T. gondii antibodies were found in 54% compared to 7% in the control group, with the difference being statistically significant (P ˂ 0.001). However, no significant correlation was found between the severity of COVID-19 and latent T. gondii infection. Latent toxoplasmosis had a strong influence on the risk of COVID-19. NO and SOD levels were significantly increased in COVID-19 patients, while GSH levels decreased significantly in them compared to control subjects (P ˂ 0.001 for both values). CRP and ferritin levels were also significantly elevated in P COVID-19 patients infected with toxoplasmosis. This is the first study to look at the importance of oxidative stress indicators in co-infection between COVID-19 and T. gondii. The high prevalence of latent toxoplasmosis in COVID-19 suggests that T. gondii infection can be considered a strong indicator of the high risk of COVID-19.
潜伏弓形虫病对气性和非气性 COVID-19 患者的影响以及相关氧化应激生物标志物的估计。
对 COVID-19 这一最具破坏性的全球流行病的易感性似乎在不同人群中差异很大。有人提出了接触弓形虫的理论来解释这些人群的多样性。本研究的目的是调查潜伏弓形虫病与 COVID-19 之间可能存在的联系,及其与氧化应激标记物、C 反应蛋白(CRP)和铁蛋白之间可能存在的相关性。在一项病例对照研究中,收集了 91 名确诊的 COVID-19 患者(48 名非肺炎型;NP,43 名肺炎型;P)和 45 名健康对照者的血样。对所有参与者进行了 IgG 抗弓形虫抗体和氧化应激标记物(一氧化氮 [NO]、超氧化物歧化酶 [SOD] 和还原型谷胱甘肽 [GSH])检测,并测定了 CRP 和血清铁蛋白水平。在 COVID-19 患者中,54% 发现了 IgG 抗淋球菌抗体,而对照组中仅有 7%,差异具有统计学意义(P ˂ 0.001)。不过,COVID-19 的严重程度与潜伏弓形虫感染之间没有发现明显的相关性。潜伏弓形虫病对 COVID-19 的风险有很大影响。与对照组相比,COVID-19 患者的 NO 和 SOD 水平明显升高,而 GSH 水平则明显下降(两个值的 P ˂ 0.001)。感染弓形虫的 P COVID-19 患者的 CRP 和铁蛋白水平也明显升高。这是首次研究氧化应激指标在 COVID-19 和弓形虫合并感染中的重要性。COVID-19 中潜伏弓形虫的高发病率表明,淋球菌感染可被视为 COVID-19 高风险的一个有力指标。
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来源期刊
Folia Parasitologica
Folia Parasitologica 医学-寄生虫学
CiteScore
2.70
自引率
0.00%
发文量
25
审稿时长
>12 weeks
期刊介绍: FOLIA PARASITOLOGICA, issued in online versions, is an international journal that covers the whole field of general, systematic, ecological and experimental parasitology. It publishes original research papers, research notes and review articles. Contributions from all branches of animal parasitology, such as morphology, taxonomy, biology, biochemistry, physiology, immunology, molecular biology and evolution of parasites, and host-parasite relationships, are eligible. Novelty and importance in the international (not local or regional) context are required. New geographical records of parasites, records of new hosts, regional parasite and/or host surveys (if they constitute the principal substance of manuscript), local/regional prevalence surveys of diseases, local/regional studies on epidemiology of well known diseases and of parasite impact on human/animal health, case reports, routine clinical studies and testing of established diagnostic or treatment procedures, will not be considered. One species description will also not be considered unless they include more general information, such as new diagnostic characters, host-parasite associations, phylogenetic implications, etc. Manuscripts found suitable on submission will be reviewed by at least two reviewers.
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