Can Pantoprazole Be Used for Premedication in Meckel Scintigraphy?

IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Molecular Imaging and Radionuclide Therapy Pub Date : 2024-04-04 DOI:10.4274/mirt.galenos.2024.48254

Aziz Gültekin, Tarık Şengöz, Samiye Demirezen, D. Yüksel

{"title":"Can Pantoprazole Be Used for Premedication in Meckel Scintigraphy?","authors":"Aziz Gültekin, Tarık Şengöz, Samiye Demirezen, D. Yüksel","doi":"10.4274/mirt.galenos.2024.48254","DOIUrl":null,"url":null,"abstract":"Objectives: Meckel scintigraphy is used to diagnose Meckel’s diverticulum. Previously, premedication with ranitidine was the most frequently used method to increase the accuracy of scintigraphy. However, ranitidine can no longer be used because it is banned by the Food and Drug Administration. The aim of this study was to investigate the usability of pantoprazole as a premedication instead of ranitidine in Meckel scintigraphy. Methods: Twelve New Zealand rabbits were used in this experimental study. Rabbits were divided into two groups: pantoprazole and control. Six rabbits were premedicated with pantoprazole for three days. Meckel scintigraphy was performed on all rabbits. Counts were made and compared by drawing regions of interest from the stomach walls. Results: According to the findings of this experimental study, pantoprazole significantly increased Tc-99m-pertechnetate uptake in the stomach of rabbits on both visual and quantitative evaluation. Conclusion: Pantoprazole increases the gastric wall uptake of Tc-99m-pertechnetate in rabbits and is a potential drug for premedication in Meckel scintigraphy.","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":null,"pages":null},"PeriodicalIF":0.9000,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Imaging and Radionuclide Therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4274/mirt.galenos.2024.48254","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: Meckel scintigraphy is used to diagnose Meckel’s diverticulum. Previously, premedication with ranitidine was the most frequently used method to increase the accuracy of scintigraphy. However, ranitidine can no longer be used because it is banned by the Food and Drug Administration. The aim of this study was to investigate the usability of pantoprazole as a premedication instead of ranitidine in Meckel scintigraphy. Methods: Twelve New Zealand rabbits were used in this experimental study. Rabbits were divided into two groups: pantoprazole and control. Six rabbits were premedicated with pantoprazole for three days. Meckel scintigraphy was performed on all rabbits. Counts were made and compared by drawing regions of interest from the stomach walls. Results: According to the findings of this experimental study, pantoprazole significantly increased Tc-99m-pertechnetate uptake in the stomach of rabbits on both visual and quantitative evaluation. Conclusion: Pantoprazole increases the gastric wall uptake of Tc-99m-pertechnetate in rabbits and is a potential drug for premedication in Meckel scintigraphy.

查看原文本刊更多论文

泮托拉唑可用于梅克尔闪烁扫描的预处理吗？

目的：梅克尔憩室闪烁照相术用于诊断梅克尔憩室。以前，使用雷尼替丁进行预处理是提高闪烁扫描准确性最常用的方法。然而，由于雷尼替丁已被美国食品和药物管理局禁用，因此不能再使用雷尼替丁。本研究旨在探讨泮托拉唑作为预处理药物替代雷尼替丁在梅克尔闪烁扫描中的可用性。研究方法本实验研究使用了 12 只新西兰兔。兔子分为两组：泮托拉唑组和对照组。六只兔子预先服用泮托拉唑三天。对所有兔子进行梅克尔闪烁扫描。通过在胃壁上绘制感兴趣区进行计数和比较。结果根据这项实验研究的结果，泮托拉唑可显著增加兔子胃中 Tc-99m-pertechnetate 的摄取量，无论是视觉评估还是定量评估均是如此。结论泮托拉唑可增加家兔胃壁对 Tc-99m-pertechnetate 的摄取，是梅克尔闪烁扫描中一种潜在的预处理药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Molecular Imaging and Radionuclide Therapy RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Molecular Imaging and Radionuclide Therapy (Mol Imaging Radionucl Ther, MIRT) is publishes original research articles, invited reviews, editorials, short communications, letters, consensus statements, guidelines and case reports with a literature review on the topic, in the field of molecular imaging, multimodality imaging, nuclear medicine, radionuclide therapy, radiopharmacy, medical physics, dosimetry and radiobiology.