Standardized Reproductive Endocrinology and Infertility Consultation for Pediatric and Adolescent Oncology Patients.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-05 DOI:10.1089/jayao.2024.0009

Lindsay A Hartup, Virginia-Arlene Go, Randal D Robinson

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引用次数: 0

Abstract

Purpose: To investigate the role of formal reproductive endocrinology and infertility (REI) consultation in fertility preservation counseling in a pediatric/adolescent oncology patient population. Methods: Retrospective chart review was performed at an academic adult hospital from 2021 to 2022. Pre- and postpubertal patients admitted to the pediatric/adolescent oncology service with cancer diagnoses and imminent gonadotoxic chemotherapy plans were included. Baseline characteristics were collected, including patient age, sex, race, language, insurance, and cancer diagnosis. Primary outcomes were formal REI consultation and fertility preservation election. Results: Nineteen of 58 eligible patients received a formal REI consultation. Patients were more likely to elect fertility preservation if they received a consult. Females were more likely to receive a consult than males and more likely to elect fertility preservation. Patients of age ≥16 years were more likely to receive consultation than younger patients. However, all patients of age <16 years who received a consult elected fertility preservation. There was no difference in consultation based on race, language, or insurance. Thirteen of 19 patients who received an REI consultation elected fertility preservation. Ten of 11 female elections were ovarian suppression, an unproven method of fertility preservation. The two male elections were semen cryopreservation. Conclusion: Underutilization of formal REI consults and a relative lack of proven fertility preservation elections may shed light on a need for increased fertility preservation awareness among young oncology patients and the providers who care for them. A streamlined process that automates formal REI consultation for all eligible patients may maximize the potential for comprehensive counseling and improve patient participation in fertility preservation.

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为儿童和青少年肿瘤患者提供标准化生殖内分泌和不孕症咨询。

目的：研究正规生殖内分泌与不孕症（REI）咨询在儿科/青少年肿瘤患者生育力保存咨询中的作用。方法：在儿童/青少年肿瘤患者中开展回顾性病历审查：2021 年至 2022 年期间，在一家学术性成人医院进行了回顾性病历审查。研究对象包括在儿科/青少年肿瘤科就诊的青春期前和青春期后、确诊为癌症且即将接受性腺毒性化疗的患者。收集的基线特征包括患者的年龄、性别、种族、语言、保险和癌症诊断。主要结果为正式的 REI 咨询和生育力保存选择。结果：58 位符合条件的患者中有 19 位接受了正式的 REI 咨询。如果接受了咨询，患者更有可能选择保留生育力。女性比男性更有可能接受咨询，也更有可能选择保留生育力。与年轻患者相比，年龄≥16 岁的患者更有可能接受咨询。然而，所有接受咨询的小于 16 岁的患者都选择了保留生育力。不同种族、语言或保险的患者在咨询方面没有差异。在接受 REI 咨询的 19 位患者中，有 13 位选择了保留生育力。11 位女性中有 10 位选择了卵巢抑制，这是一种未经证实的生育力保存方法。两名男性选择了精液冷冻保存。结论：正规 REI 咨询的利用率不足以及相对缺乏经证实的生育力保存选择，可能说明年轻肿瘤患者和为他们提供护理的医疗人员需要提高生育力保存意识。为所有符合条件的患者自动提供正式 REI 咨询的简化流程可能会最大限度地发挥全面咨询的潜力，并提高患者对生育力保存的参与度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.