COVID-19 mortality in 1984 Bhopal gas tragedy survivors: implications for chemically exposed populations.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-08 DOI:10.1093/trstmh/trae010

Rachna Dhingra, S. Sarangi, Pranab Chatterjee, Arkaprabha Gun, Swarup Sarkar

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引用次数: 0

Abstract

Leakage of methyl isocyanate from the Union Carbide plant in Bhopal, India, killed thousands and left deleterious trans-generational effects. Gas-exposed populations experience higher rates of lung and metabolic diseases, and immune dysregulation, all associated with adverse outcomes in coronavirus disease 2019 (COVID-19). We used publicly available, official data from government sources to estimate COVID-19-associated crude mortality in populations with and without a history of gas exposure. Overall, there were 1240 deaths among patients hospitalized with known COVID-19 in Bhopal, of which 453 (36.53%) were in gas-exposed individuals, 726 (58.55%) were in gas-unexposed individuals and the exposure status of 61 (4.92%) individuals could not be determined. There were 351 and 375 deaths in gas-unexposed people in the first (April 2020-February 2021) and second (March 2021-July 2021) waves, respectively; in the gas-exposed population, there were 300 and 153 deaths in the two respective waves. The overall annualized crude mortality of COVID-19 was 3.84 (95% CI 3.41 to 4.33) times higher in the gas-exposed population at 83.6 (95% CI 76.1 to 91.7) per 100 000 compared with the gas-unexposed population, at 21.8 (95% CI 20.2 to 23.4) per 100,000. When stratified by age, compared with unexposed people, the gas-exposed individuals experienced 1.88 (95% CI 1.61 to 2.21) and 1.24 (95% CI 1.02 to 1.50) times the mortality rates in the age groups of 35-65 and >65 y, respectively. These findings indicate that gas-exposed individuals are likely to have a higher risk of severe COVID-19 and death and need to be specifically targeted and recognized for preventive and promotive efforts.

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1984 年博帕尔毒气悲剧幸存者的 COVID-19 死亡率：对接触化学品人群的影响。

印度博帕尔的联合碳化物工厂泄漏的异氰酸甲酯造成数千人死亡，并留下了有害的跨代影响。接触过毒气的人群患肺病、代谢性疾病和免疫失调的比例较高，这些都与 2019 年冠状病毒疾病（COVID-19）的不良后果有关。我们利用政府来源的公开官方数据，估算了有煤气暴露史和无煤气暴露史人群中与 COVID-19 相关的粗死亡率。总体而言，博帕尔市因已知 COVID-19 而住院的患者中有 1240 人死亡，其中 453 人（36.53%）接触过毒气，726 人（58.55%）未接触过毒气，61 人（4.92%）的接触状况无法确定。在第一波（2020 年 4 月至 2021 年 2 月）和第二波（2021 年 3 月至 2021 年 7 月）中，未暴露于煤气的人群分别有 351 人和 375 人死亡；在暴露于煤气的人群中，两波分别有 300 人和 153 人死亡。与未暴露于气体的人群每 10 万人 21.8 例（95% CI 20.2 至 23.4 例）的死亡率相比，暴露于气体的人群每 10 万人 83.6 例（95% CI 76.1 至 91.7 例）的 COVID-19 总年化粗死亡率高出 3.84 倍（95% CI 3.41 至 4.33 倍）。如果按年龄分层，与未暴露于气体的人群相比，暴露于气体的人群在 35-65 岁和大于 65 岁年龄组的死亡率分别是未暴露于气体人群的 1.88 倍（95% CI 1.61 至 2.21）和 1.24 倍（95% CI 1.02 至 1.50）。这些研究结果表明，接触过煤气的人患严重 COVID-19 和死亡的风险可能较高，因此需要专门针对并认识到这一点来开展预防和促进工作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.