Evaluation of autologous fat grafting in the treatment of juvenile localized scleroderma with facial involvement

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-08 DOI:10.1177/23971983241241099

Louise Sander, I. Foeldvari, Daniel Glaser, J. Klotsche, Rebecca Stier, Juan Camilo Roldán

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引用次数: 0

Abstract

The objective of this study was to evaluate the effect of autologous fat grafting in patients with juvenile localized scleroderma with facial involvement. We retrospectively studied patients with juvenile localized scleroderma who were followed at the Hamburg Center for Pediatric and Adolescent Rheumatology at least 6 months post-operative follow-up and received at least one autologous fat transplantation for a facial lesion. Autologous fat grafting was conducted independent of disease-modifying treatment and/or disease activity. The effectiveness of the intervention was evaluated by assessing the immediate volume enhancement after injection of fat tissue compared with volume retained after 6 months. The volume enhancement was calculated from three-dimensional photo images analyzed in Mirror Medical Imaging Software, Canfield Scientific (New Jersey, USA). Data of 22 juvenile patients were assessed from March 2006 to September 2021. In six patients, the photos could not be evaluated for the study. The median age of the remaining 16 patients at the beginning of the first fat graft was 8 years (range = 2.5–22 years). Patients underwent mean three interventions (range = 1–9). Evaluation of three-dimensional images showed that the volume retention at 6 months post autologous fat grafting is approximately 50%. The Modified Localized Scleroderma Skin Severity Index value did not correlate to volume changes at 6 months. In 4 of 16 patients, a decrease of the Localized Scleroderma Damage Index occurred. In all seven patients with cheek involvement, mean tragus-nose distance difference decreased (mean decrease 1.09 cm). We did not observe any significant clinical side effects. In this first bigger pediatric case series, the mean facial lesion volume increased around 50% after a mean of three interventions at 25 months of follow-up. No flares of the underlying disease were noted. Autologous fat grafting is a promising method to improve the cosmetic appearance of those patients.

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评估自体脂肪移植在治疗面部受累的幼年局部硬皮病中的效果

这项研究的目的是评估自体脂肪移植对面部受累的幼年局部硬皮病患者的影响。我们对汉堡儿童与青少年风湿病学中心随访的幼年局部硬皮病患者进行了回顾性研究，这些患者在术后随访至少6个月，并至少接受过一次面部病变自体脂肪移植手术。自体脂肪移植与疾病调节治疗和/或疾病活动无关。通过评估注射脂肪组织后立即增加的容积与 6 个月后保留的容积进行比较，以评估干预的有效性。体积增大是通过美国新泽西州 Canfield Scientific 公司的 Mirror 医学影像软件分析的三维照片图像计算得出的。从 2006 年 3 月到 2021 年 9 月，对 22 名青少年患者的数据进行了评估。有 6 名患者的照片无法在研究中进行评估。其余16名患者在首次脂肪移植开始时的中位年龄为8岁（范围=2.5-22岁）。患者平均接受了三次干预（范围 = 1-9）。三维图像评估显示，自体脂肪移植术后 6 个月的容积保持率约为 50%。改良局部硬皮病皮肤严重程度指数值与 6 个月时的容积变化无关。16 位患者中有 4 位的局部硬皮病损伤指数有所下降。在所有 7 位面颊受累的患者中，拇指与鼻的平均距离差有所缩小（平均缩小 1.09 厘米）。我们没有观察到任何明显的临床副作用。在这个首例较大的儿科病例系列中，平均三次干预后，面部病变体积增加了约 50%，随访时间为 25 个月。未发现潜在疾病复发。自体脂肪移植是一种很有前景的方法，可以改善这些患者的外观。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.