The Bitemporal Lens Model—toward a holistic approach to chronic disease prevention with digital biomarkers

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-04-08 DOI:10.1093/jamiaopen/ooae027

F. Barata, Jinjoo Shim, Fan Wu, Patrick Langer, E. Fleisch

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引用次数: 0

Abstract

Abstract Objectives We introduce the Bitemporal Lens Model, a comprehensive methodology for chronic disease prevention using digital biomarkers. Materials and Methods The Bitemporal Lens Model integrates the change-point model, focusing on critical disease-specific parameters, and the recurrent-pattern model, emphasizing lifestyle and behavioral patterns, for early risk identification. Results By incorporating both the change-point and recurrent-pattern models, the Bitemporal Lens Model offers a comprehensive approach to preventive healthcare, enabling a more nuanced understanding of individual health trajectories, demonstrated through its application in cardiovascular disease prevention. Discussion We explore the benefits of the Bitemporal Lens Model, highlighting its capacity for personalized risk assessment through the integration of two distinct lenses. We also acknowledge challenges associated with handling intricate data across dual temporal dimensions, maintaining data integrity, and addressing ethical concerns pertaining to privacy and data protection. Conclusion The Bitemporal Lens Model presents a novel approach to enhancing preventive healthcare effectiveness.

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位时透镜模型--利用数字生物标记物全面预防慢性病

摘要目的我们介绍了双时相透镜模型（Bitemporal Lens Model），这是一种利用数字生物标记物预防慢性疾病的综合方法。材料与方法位时透镜模型整合了变化点模型（侧重于关键的疾病特异性参数）和复发模式模型（侧重于生活方式和行为模式），用于早期风险识别。结果双时相透镜模型结合了变化点模型和复发模式模型，为预防性保健提供了一种全面的方法，使人们能够更细致地了解个人的健康轨迹，这一点通过其在心血管疾病预防中的应用得到了证明。讨论我们探讨了双时空透镜模型的优点，强调了它通过整合两个不同透镜进行个性化风险评估的能力。同时，我们也认识到在处理双时空维度的复杂数据、维护数据完整性以及解决与隐私和数据保护相关的伦理问题时所面临的挑战。结论双时相透镜模型为提高预防性医疗保健的有效性提供了一种新方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.