Novel automated AIMLAM for diagnosis of Mycobacterium tuberculosis.

IF 2.5 4区生物学 Q3 MICROBIOLOGY

Future microbiology Pub Date : 2024-04-09 DOI:10.2217/fmb-2024-0025

Ruixia Liang, Jiankang Li, Hongmei Shi, Wu Han, Zhao Chang

引用次数: 0

Abstract

Aim: A rapid and precise diagnostic method is crucial for timely intervention and management of tuberculosis. The present study compared the diagnostic accuracy of a novel lipoarabinomannan (LAM) antigen test, AIMLAM, for tuberculosis in urine samples. Methodology: The study subjected 106 TB suspects to smear microscopy, MGIT, GeneXpert and AIMLAM. Results: Among 106, smear microscopy identified 36 as positive (33%) (sensitivity; 70.93%, 95% CI (60.14-80.22%), while MGIT showed 38 positive (36.8%). GeneXpert detected 59 positives (sensitivity; 96.83, 95% CI (89.00-99.61%)). AIMLAM declared 61 as positive (57.5%) (sensitivity; 100.00, 95% CI (94.13-100.00%) and 45 as negative (42.5%). Conclusion: Overall, AIMLAM demonstrated better diagnostic accuracy than GeneXpert Assay, smear microscopy and MGIT liquid culture in urine samples.

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用于诊断结核分枝杆菌的新型自动化 AIMLAM。

目的：快速准确的诊断方法对于及时干预和治疗结核病至关重要。本研究比较了新型脂联素甘露聚糖（LAM）抗原检测法 AIMLAM 对尿液样本中结核病的诊断准确性。研究方法研究对 106 名肺结核疑似患者进行涂片显微镜检查、MGIT、GeneXpert 和 AIMLAM 检测。结果：在 106 人中，涂片显微镜检查发现 36 人呈阳性（33%）（灵敏度为 70.93%，95% CI 为 60.14-80.22%），而 MGIT 检查显示 38 人呈阳性（36.8%）。GeneXpert 检测出 59 例阳性（灵敏度为 96.83%，95% CI 为 89.00-99.61%）。AIMLAM 宣布 61 例为阳性（57.5%）（灵敏度为 100.00，95% CI 为 94.13-100.00%），45 例为阴性（42.5%）。结论总体而言，在尿液样本中，AIMLAM 比 GeneXpert 分析、涂片显微镜检查和 MGIT 液体培养显示出更高的诊断准确性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future microbiology 生物-微生物学

CiteScore

4.90

自引率

3.20%

发文量

134

审稿时长

6-12 weeks

期刊介绍： Future Microbiology delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this increasingly important and vast area of research.