Transethosomal Carrier of Curcumin for Improved Topical Delivery: Optimization, In-vitro and Stability Assessment

Abstract

Currently, there is a clear lack of effective topical treatments for psoriasis. In light of this unaddressed requirement, the work intends to develop, enhance, and assess the effectiveness of a curcumin transethosomal gel for managing psoriasis. This work signifies the delivery of a potential solution to fill the gap in topical psoriasis treatment. Curcumin-loaded transethosomes were prepared using a mechanical dispersion method. An initial study was conducted to determine the ideal concentrations of Lipoid S100 and Isopropyl Myristate (IPM). To refine the ultimate transethosomal formulation, a full factorial design (32) was employed, incorporating different levels of Lipoid S100 and IPM. Drug release investigations and pharmacokinetics assessments of curcumin concentrations were performed using a specialized dissolution apparatus and an animal model, respectively. The characterization profile and analytical examinations have affirmed the stability of the formulation throughout the study duration. Our findings indicate that the drug release mechanism conforms to a diffusion pattern akin to Fickian transport. Furthermore, In-vivo investigations revealed that the curcumin concentration in the bloodstream after oral administration was significantly superior to that of the conventional formulation. Using curcumin-loaded transethosomes extends drug contact time and facilitates controlled drug release, leading to enhanced bioavailability, decreased dosage needs, and heightened patient safety.