Pharmacokinetics of tilmicosin in plasma, urine and feces after a single intragastric administration in donkey (Equus asinus)

IF 1.5 4区农林科学 Q3 PHARMACOLOGY & PHARMACY

Journal of veterinary pharmacology and therapeutics Pub Date : 2024-04-10 DOI:10.1111/jvp.13446

Bowen Yang, Shijie Liu, Yanxin Guo, Honglei Qu, Yulong Feng, Yantao Wang, Boying Dong, Yanjie Dong, Shancang Zhao, Shimeng Huang, Lihong Zhao, Jianyun Zhang, Cheng Ji, Qiugang Ma

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Abstract

Tilmicosin, a macrolide antibiotic, has the potential to treat bacterial infections in donkeys. However, the pharmacokinetics of tilmicosin in donkeys have not been reported. The aim of this study was to investigate the pharmacokinetics of tilmicosin in donkey plasma, urine, and feces after a single intragastric administration to determine the suitability of tilmicosin for donkeys. A total of 5 healthy male donkeys with similar body weights were selected. The donkeys were administered a single dose of 10 mg · kg⁻¹ body weight (BW) tilmicosin by gavage. The concentrations of tilmicosin in plasma, urine, and feces were determined. The results showed that after a single intragastric administration of 10 mg · kg⁻¹ body weight, tilmicosin in donkey plasma reached a maximum concentration of 11.23 ± 5.37 mg · L⁻¹ at 0.80 ± 0.10 h, with a half-life of 14.49 ± 7.13 h, a mean residence time of 28.05 ± 3.05 h, a Cl/F of 0.48 ± 0.18 L · kg⁻¹ · h⁻¹, and a Vd/F of 9.28 ± 2.63 Lkg⁻¹. The percentage of tilmicosin excreted through the urine of donkeys is 2.47%, and the percentage excreted through the feces is 66.43%. Our study provides data to inform the use of tilmicosin in donkeys.

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驴（Equus asinus）一次胃内给药后血浆、尿液和粪便中替米考星的药代动力学。

替米考星是一种大环内酯类抗生素，具有治疗驴细菌感染的潜力。然而，驴体内替米考星的药代动力学尚未见报道。本研究的目的是调查驴一次胃内给药后血浆、尿液和粪便中替米考星的药代动力学，以确定替米考星是否适用于驴。共挑选了 5 头体重相近的健康雄驴。给驴灌胃单剂量 10 毫克-千克-1 体重（BW）替米考星。测定血浆、尿液和粪便中替米考星的浓度。结果表明，一次胃内给药 10 毫克-千克-1 体重后，驴血浆中替米考星的最大浓度在 0.80 ± 0.10 小时内达到 11.23 ± 5.37 毫克-升-1，半衰期为 14.49 ± 7.13 小时，平均停留时间为 28.05 ± 3.05 小时，Cl/F 为 0.48 ± 0.18 升-千克-1 -小时-1，Vd/F 为 9.28 ± 2.63 升-千克-1。通过驴尿排泄的替米考星比例为 2.47%，通过粪便排泄的比例为 66.43%。我们的研究为驴使用替米考星提供了数据依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of veterinary pharmacology and therapeutics 农林科学-兽医学

CiteScore

3.10

自引率

15.40%

发文量

审稿时长

8-16 weeks

期刊介绍： The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.