Associations between vitamin D status, VDR gene polymorphisms and echocardiographic markers in Polish patients with cardiovascular disease.

IF 1.6 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Future cardiology Pub Date : 2024-04-10 DOI:10.2217/fca-2023-0129

Mohamed Abouzid, Paweł Burchardt, Leonid Kagan, F. Główka, Marta Karaźniewicz-Łada

引用次数: 0

Abstract

Aim: This work was designed to investigate the associations between vitamin D metabolites, VDR gene polymorphisms and echocardiographic markers in a population of patients with cardiovascular disease. Methods: Echocardiographic markers for 42 patients were determined with tissue Doppler techniques. PCR-restriction fragment length polymorphism analysis identified genetic variants ApaI, TaqI, BsmI and FokI. A validated UHPLC-MS/MS method determined vitamin D metabolites. Results: Patients with the ApaI-GT genotype exhibited a lower pressure gradient across the aortic valve than ApaI-TT carriers. BMI, ApaI-GT, TaqI-TC, aortic arch diameter and maximal pressure gradient were significant univariate predictors of hypertension. Conclusion: A potential link exists between VDR gene polymorphisms and cardiovascular function.

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波兰心血管疾病患者的维生素 D 状态、VDR 基因多态性和超声心动图标记之间的关系。

目的：本研究旨在调查心血管疾病患者群体中维生素 D 代谢物、VDR 基因多态性和超声心动图标记之间的关联。研究方法采用组织多普勒技术测定 42 名患者的超声心动图指标。PCR-限制性片段长度多态性分析确定了 ApaI、TaqI、BsmI 和 FokI 基因变异。一种经过验证的超高效液相色谱-质谱/质谱方法测定了维生素 D 代谢物。结果显示与 ApaI-TT 基因型携带者相比，ApaI-GT 基因型患者主动脉瓣压力梯度较低。体重指数、ApaI-GT、TaqI-TC、主动脉弓直径和最大压力梯度是高血压的重要单变量预测因素。结论VDR 基因多态性与心血管功能之间存在潜在联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.80

自引率

5.90%

发文量

期刊介绍： Research advances have contributed to improved outcomes across all specialties, but the rate of advancement in cardiology has been exceptional. Concurrently, the population of patients with cardiac conditions continues to grow and greater public awareness has increased patients" expectations of new drugs and devices. Future Cardiology (ISSN 1479-6678) reflects this new era of cardiology and highlights the new molecular approach to advancing cardiovascular therapy. Coverage will also reflect the major technological advances in bioengineering in cardiology in terms of advanced and robust devices, miniaturization, imaging, system modeling and information management issues.