Associations between vitamin D status, VDR gene polymorphisms and echocardiographic markers in Polish patients with cardiovascular disease.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-10 DOI:10.2217/fca-2023-0129

Mohamed Abouzid, Paweł Burchardt, Leonid Kagan, F. Główka, Marta Karaźniewicz-Łada

引用次数: 0

Abstract

Aim: This work was designed to investigate the associations between vitamin D metabolites, VDR gene polymorphisms and echocardiographic markers in a population of patients with cardiovascular disease. Methods: Echocardiographic markers for 42 patients were determined with tissue Doppler techniques. PCR-restriction fragment length polymorphism analysis identified genetic variants ApaI, TaqI, BsmI and FokI. A validated UHPLC-MS/MS method determined vitamin D metabolites. Results: Patients with the ApaI-GT genotype exhibited a lower pressure gradient across the aortic valve than ApaI-TT carriers. BMI, ApaI-GT, TaqI-TC, aortic arch diameter and maximal pressure gradient were significant univariate predictors of hypertension. Conclusion: A potential link exists between VDR gene polymorphisms and cardiovascular function.

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波兰心血管疾病患者的维生素 D 状态、VDR 基因多态性和超声心动图标记之间的关系。

目的：本研究旨在调查心血管疾病患者群体中维生素 D 代谢物、VDR 基因多态性和超声心动图标记之间的关联。研究方法采用组织多普勒技术测定 42 名患者的超声心动图指标。PCR-限制性片段长度多态性分析确定了 ApaI、TaqI、BsmI 和 FokI 基因变异。一种经过验证的超高效液相色谱-质谱/质谱方法测定了维生素 D 代谢物。结果显示与 ApaI-TT 基因型携带者相比，ApaI-GT 基因型患者主动脉瓣压力梯度较低。体重指数、ApaI-GT、TaqI-TC、主动脉弓直径和最大压力梯度是高血压的重要单变量预测因素。结论VDR 基因多态性与心血管功能之间存在潜在联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.