Preventive and Therapeutic Benefits of Natural Ingredients in Photo-Induced Epidermal Dysfunction.

IF 2.8 4区医学 Q2 DERMATOLOGY

Skin Pharmacology and Physiology Pub Date : 2024-04-12 DOI:10.1159/000538832

Dongyun Lei, L. Ye, S. Wen, Junling Zhang, Litao Zhang, Mao-Qiang Man

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Abstract

BACKGROUND The skin, particularly the epidermis, is subjected to various external stresses, including ultraviolet [UV] irradiation. UV irradiation, mainly UVB at wavelength of 280-315 nm, can alter several epidermal functions, including cutaneous inflammation, epidermal hyperproliferation, DNA damage, disruption of epidermal permeability barrier and reduction in stratum corneum hydration levels. Because of the negative impacts of UVB irradiation on epidermal functions, great efforts have been made to develop regimens for the protection of alterations in epidermal function induced by UV irradiation. SUMMARY While sunscreen can provide physical barrier to UV light, some natural ingredients can also effectively protect the skin from UVB irradiation-induced damages. Studies have demonstrated that either topical or oral administrations of some natural ingredients attenuate UVB irradiation-induced alterations in the epidermal function. The underlying mechanisms by which natural ingredients improve epidermal functions are attributable to antioxidation, stimulation of keratinocyte differentiation, increases in the content of epidermal natural moisturizers and inhibition of inflammation. KEY MESSAGE Some natural ingredients exhibit protective and therapeutical benefits in photo-induced epidermal dysfunctions via divergent mechanisms.

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天然成分对光诱发的表皮功能障碍的预防和治疗作用。

背景皮肤，尤其是表皮，承受着各种外部压力，包括紫外线辐照。紫外线照射（主要是波长为 280-315 纳米的 UVB）可改变表皮的多种功能，包括皮肤炎症、表皮过度增殖、DNA 损伤、表皮渗透屏障破坏和角质层水合水平降低。由于紫外线照射会对表皮功能产生负面影响，因此人们一直在努力开发各种方案，以保护表皮功能免受紫外线照射引起的改变。摘要虽然防晒霜可以提供抵御紫外线的物理屏障，但一些天然成分也能有效保护皮肤免受紫外线照射引起的损害。研究表明，局部或口服某些天然成分可减轻紫外线照射引起的表皮功能改变。天然成分改善表皮功能的基本机制包括抗氧化、刺激角质细胞分化、增加表皮天然保湿剂的含量以及抑制炎症。

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来源期刊

Skin Pharmacology and Physiology 医学-皮肤病学

CiteScore

5.20

自引率

7.40%

发文量

审稿时长

>12 weeks

期刊介绍： In the past decade research into skin pharmacology has rapidly developed with new and promising drugs and therapeutic concepts being introduced regularly. Recently, the use of nanoparticles for drug delivery in dermatology and cosmetology has become a topic of intensive research, yielding remarkable and in part surprising results. Another topic of current research is the use of tissue tolerable plasma in wound treatment. Stimulating not only wound healing processes but also the penetration of topically applied substances into the skin, this novel technique is expected to deliver very interesting results.