Serum testosterone levels and oxidative stress in type 1 diabetes, type 2 diabetes, and obesity.

H. Ellidağ, R. Aslankoç, Mehmet Kök, G. Aykal, Özgür Aydın, Özlem Özmen, Remzi Can Çakır, U. Doğan
{"title":"Serum testosterone levels and oxidative stress in type 1 diabetes, type 2 diabetes, and obesity.","authors":"H. Ellidağ, R. Aslankoç, Mehmet Kök, G. Aykal, Özgür Aydın, Özlem Özmen, Remzi Can Çakır, U. Doğan","doi":"10.5603/ep.98190","DOIUrl":null,"url":null,"abstract":"INTRODUCTION\nObesity, type 1 diabetes mellitus (T1DM), and type 2 diabetes mellitus (T2DM) are metabolic diseases that continue to be a global problem. Testosterone levels in men are affected by several factors, including obesity and DM. Although the relationship between diabetes and testosterone is not fully understood, oxidative stress is thought to play a major role. The aim of this study was to compare serum testosterone levels and oxidative stress markers [total antioxidant status (TAS), total oxidant capacity (TOS), oxidative stress index (OSI), and ischaemic modified albumin (IMA)] among the control group and experimentally induced obese, T1DM, and T2DM rats.\n\n\nMATERIAL AND METHODS\nThe study included 28 male Sprague-Dawley rats divided into 4 groups: the obesity group were fed a high-fat diet (HFD), the T2DM group received a HFD plus a single dose of streptozocin (STZ), the T1DM group received only STZ, and there was a control group. Serum testosterone, TAS, TOS, OSI, and IMA were analysed.\n\n\nRESULTS\nSerum testosterone levels were lower in the T1DM and T2DM groups compared to the control and obesity groups. The TOS levels were highest in the T2DM group, followed by the T1DM group, the obesity group, and finally the control group. No significant difference was found between the obesity group and the control group in terms of TOS levels. Regarding TAS levels, the order observed was control group > obesity group > T2DM > T1DM. Testosterone was positively correlated with TAS and negatively correlated with TOS and OSI.\n\n\nCONCLUSIONS\nIncreased oxidative stress in diabetes may be an important factor that decreases serum testosterone levels.","PeriodicalId":93990,"journal":{"name":"Endokrynologia Polska","volume":"18 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endokrynologia Polska","FirstCategoryId":"0","ListUrlMain":"https://doi.org/10.5603/ep.98190","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

INTRODUCTION Obesity, type 1 diabetes mellitus (T1DM), and type 2 diabetes mellitus (T2DM) are metabolic diseases that continue to be a global problem. Testosterone levels in men are affected by several factors, including obesity and DM. Although the relationship between diabetes and testosterone is not fully understood, oxidative stress is thought to play a major role. The aim of this study was to compare serum testosterone levels and oxidative stress markers [total antioxidant status (TAS), total oxidant capacity (TOS), oxidative stress index (OSI), and ischaemic modified albumin (IMA)] among the control group and experimentally induced obese, T1DM, and T2DM rats. MATERIAL AND METHODS The study included 28 male Sprague-Dawley rats divided into 4 groups: the obesity group were fed a high-fat diet (HFD), the T2DM group received a HFD plus a single dose of streptozocin (STZ), the T1DM group received only STZ, and there was a control group. Serum testosterone, TAS, TOS, OSI, and IMA were analysed. RESULTS Serum testosterone levels were lower in the T1DM and T2DM groups compared to the control and obesity groups. The TOS levels were highest in the T2DM group, followed by the T1DM group, the obesity group, and finally the control group. No significant difference was found between the obesity group and the control group in terms of TOS levels. Regarding TAS levels, the order observed was control group > obesity group > T2DM > T1DM. Testosterone was positively correlated with TAS and negatively correlated with TOS and OSI. CONCLUSIONS Increased oxidative stress in diabetes may be an important factor that decreases serum testosterone levels.
1 型糖尿病、2 型糖尿病和肥胖症患者的血清睾酮水平和氧化应激。
导言肥胖、1 型糖尿病(T1DM)和 2 型糖尿病(T2DM)是持续存在的全球性代谢疾病。男性睾酮水平受多种因素影响,包括肥胖和糖尿病。尽管糖尿病与睾酮之间的关系尚未完全明了,但氧化应激被认为在其中扮演了重要角色。本研究旨在比较对照组和实验诱导的肥胖、T1DM 和 T2DM 大鼠的血清睾酮水平和氧化应激指标[总抗氧化状态(TAS)、总氧化能力(TOS)、氧化应激指数(OSI)和缺血修饰白蛋白(IMA)]。材料和方法该研究将 28 只雄性 Sprague-Dawley 大鼠分为 4 组:肥胖组喂食高脂饮食(HFD),T2DM 组喂食 HFD 和单剂量链脲佐菌素(STZ),T1DM 组只喂食 STZ,还有一个对照组。结果与对照组和肥胖组相比,T1DM 组和 T2DM 组的血清睾酮水平较低。T2DM 组的 TOS 水平最高,其次是 T1DM 组、肥胖组,最后是对照组。肥胖组和对照组的 TOS 水平没有明显差异。在 TAS 水平方面,观察到的顺序是对照组 > 肥胖组 > T2DM > T1DM。结论糖尿病患者氧化应激增加可能是降低血清睾酮水平的一个重要因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
0.60
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信