Effects of robot-assisted upper limb training combined with intermittent theta burst stimulation (iTBS) on cortical activation in stroke patients: A functional near-infrared spectroscopy study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-13 DOI:10.3233/nre-230355

Lei Dai, Wanying Zhang, Huihuang Zhang, Linjie Fang, Jianer Chen, Xiang Li, Hong Yu, Jianfei Song, Shishi Chen, Beisi Zheng, Yujia Zhang, Zhongyi Li

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Abstract

BACKGROUND The therapeutic effect and mechanism of robot-assisted upper limb training (RT) combined with intermittent theta burst stimulation (iTBS) for stroke patients are unclear. OBJECTIVE The purpose of this study was to evaluate changes in brain activation after combination therapy and RT alone using functional near-infrared spectroscopy (fNIRS). METHODS Patients were randomly assigned to two groups (iTBS + RT Group, n = 18, and RT Group, n = 18). Training was conducted five times a week for four weeks. fNIRS was used to measure changes in oxyhemoglobin in both the primary motor cortex (M1) and pre-motor and supplementary motor area (pSMA) during affected limb movement. Fugl-Meyer Assessment-Upper Extremity (FMA-UE) was employed for evaluating the function of upper limbs. RESULTS Thirty-two patients with subacute stroke completed the study. The cortex of both hemispheres was extensively activated prior to treatment in the RT group. After training, overactivation decreased. The brain activation of the combined treatment group transferred to the affected side after the treatment. There was a notable enhancement in the FMA-UE scores for both groups, with the combined group's progress significantly surpassing that of the RT group. CONCLUSION RT combined with iTBS can improve the motor function of stroke patients and promote the balance between cerebral hemispheres.

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机器人辅助上肢训练结合间歇θ脉冲刺激（iTBS）对中风患者皮质激活的影响：功能性近红外光谱研究。

背景机器人辅助上肢训练（RT）结合间歇性θ脉冲刺激（iTBS）对脑卒中患者的治疗效果和机制尚不清楚。目的本研究旨在使用功能性近红外光谱（fNIRS）评估联合疗法和单独 RT 治疗后大脑激活的变化。使用 fNIRS 测量受影响肢体运动时初级运动皮层 (M1) 和前运动区及辅助运动区 (pSMA) 中氧合血红蛋白的变化。结果32名亚急性脑卒中患者完成了研究。RT 组患者在治疗前大脑两半球皮层被广泛激活。训练后，过度激活现象有所减少。治疗后，联合治疗组的大脑激活转移到了患侧。两组的 FMA-UE 评分均有显著提高，联合治疗组的进步明显超过 RT 组。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.