Transfusion transmissible malaria: seroprevalence of malaria parasitemia in blood donors in Garhwal region of Uttarakhand, India

IF 1.3 Q4 MICROBIOLOGY

Iranian Journal of Microbiology Pub Date : 2024-04-15 DOI:10.18502/ijm.v16i2.15360

Naveen Bansal, Y. Bansal, Charu Singh, Vandita Pahwa, Satish Kumar

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Abstract

Background and Objectives: Malaria was the first ever reported case of transfusion transmitted infection (TTI). Transfusion transmissible malaria (TTM) can result in febrile transfusion reaction in the recipient. TTM can be fatal if the blood transfu- sion recipient is from vulnerable population i.e. pregnant women or young children. Therefore, the present study was done to estimate the seroprevalence of malaria parasitemia among blood donors in Garhwal region. Materials and Methods: Study subjects were healthy blood donors who had passed the screening criteria for blood do- nation. Donors with a history of malaria were temporarily deferred for 3 months following full recovery. Screening of the donated blood units for malaria parasite was done using immunochromatography based rapid diagnostic test. Thin smear examination was performed for malaria parasite species identification. Results: A total of 1984 blood donations were screened for TTI. The seroprevalence of HBV, HCV HIV and syphilis was 0.3% (n=6), 0.25% (n=5), 0% (n=0) and 0% (n=0) respectively. The seroprevalence of malaria parasite was 0.05% (n=1). Plasmodium vivax was identified upon thin smear examination. The donor reactive for malaria parasite was a replacement donor and gave no recent history of fever or any past history of malaria. Conclusion: Meticulous donor screening combined with rapid diagnostic tests for malaria parasite is the most practical strategy to prevent TTM in Garhwal region of India.

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输血传播性疟疾：印度北阿坎德邦 Garhwal 地区献血者的疟疾寄生虫血清流行率

背景和目的：疟疾是有史以来报告的首例输血传播感染（TTI）病例。输血传播性疟疾（TTM）可导致受血者出现发热性输血反应。如果输血者是易感人群（如孕妇或幼儿），输血传播性疟疾可能是致命的。因此，本研究旨在估算 Garhwal 地区献血者的疟疾寄生虫血清阳性率。材料和方法：研究对象为通过献血筛查标准的健康献血者。有疟疾病史的献血者在完全康复后暂时推迟 3 个月。使用基于免疫层析技术的快速诊断测试对献血单位进行疟原虫筛查。薄层涂片检查用于鉴定疟原虫的种类。结果共对 1984 份献血进行了 TTI 筛查。乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）、艾滋病毒（HIV）和梅毒的血清阳性率分别为 0.3%（6 人）、0.25%（5 人）、0%（0 人）和 0%（0 人）。疟原虫血清阳性率为 0.05%（n=1）。薄涂片检查确定了间日疟原虫。对疟原虫有反应的捐献者是替补捐献者，近期没有发烧史或疟疾既往史。结论在印度加瓦尔地区，对捐献者进行严格筛查并结合疟原虫快速诊断检测是预防 TTM 的最实用策略。

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来源期刊

Iranian Journal of Microbiology MICROBIOLOGY-

CiteScore

2.40

自引率

7.10%

发文量

审稿时长

12 weeks

期刊介绍： The Iranian Journal of Microbiology (IJM) is an international, multi-disciplinary, peer-reviewed journal that provides rapid publication of the most advanced scientific research in the areas of basic and applied research on bacteria and other micro-organisms, including bacteria, viruses, yeasts, fungi, microalgae, and protozoa concerning the development of tools for diagnosis and disease control, epidemiology, antimicrobial agents, clinical microbiology, immunology, Genetics, Genomics and Molecular Biology. Contributions may be in the form of original research papers, review articles, short communications, case reports, technical reports, and letters to the Editor. Research findings must be novel and the original data must be available for review by the Editors, if necessary. Studies that are preliminary, of weak originality or merely descriptive as well as negative results are not appropriate for the journal. Papers considered for publication must be unpublished work (except in an abstract form) that is not under consideration for publication anywhere else, and all co-authors should have agreed to the submission. Manuscripts should be written in English.