Eosinophil-Count-Derived Inflammatory Markers and Psoriasis Severity: Exploring the Link

Dermato Pub Date : 2024-04-15 DOI:10.3390/dermato4020004
Oana Mirela Tiucă, S. H. Morariu, Claudia Raluca Mariean, Robert Aurelian Tiucă, A. Nicolescu, O. Cotoi
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Abstract

Psoriasis is an immune-mediated disease, with various triggering factors, genetic predisposition, and an altered immune response concurring in the development of this disease. The eosinophil is a cell with an important role in various kinds of inflammatory processes. Scarce data are available regarding the role of the eosinophil in psoriasis. This study aims to address the overall relationship between eosinophil-count-derived inflammatory markers and psoriasis severity. There were 366 patients fulfilling the inclusion criteria included in this retrospective study and they were divided based on the body surface area (BSA) scale in mild and moderate-to-severe psoriasis. White blood cell (WBC), neutrophil, lymphocyte, monocyte, and eosinophil count, along with eosinophil-to-monocyte ratio (EMR) and eosinophil-to-neutrophil ratio (ENR) differed significantly between the two study groups. Eosinophil count, EMR, and ENR negatively correlated with disease severity. ENR is the most reliable eosinophil-count-derived marker in assessing psoriasis severity with an AUC of 0.627 and a cut-off value of 0.03. Eosinophil-count-derived inflammatory markers’ usefulness in appreciating disease severity was assessed for the first time in the literature in this study and proved to be reliable for the eosinophil count, EMR, and ENR.
嗜酸性粒细胞计数衍生的炎症标记物与牛皮癣严重程度:探索联系
银屑病是一种免疫介导的疾病,发病与各种诱发因素、遗传易感性和免疫反应改变有关。嗜酸性粒细胞是一种在各种炎症过程中发挥重要作用的细胞。有关嗜酸性粒细胞在银屑病中的作用的数据十分稀少。本研究旨在探讨嗜酸性粒细胞数量衍生的炎症指标与银屑病严重程度之间的总体关系。这项回顾性研究共纳入了 366 名符合纳入标准的患者,并根据体表面积(BSA)将他们分为轻度和中重度银屑病患者。两个研究组的白细胞(WBC)、中性粒细胞、淋巴细胞、单核细胞和嗜酸性粒细胞计数以及嗜酸性粒细胞与单核细胞比值(EMR)和嗜酸性粒细胞与中性粒细胞比值(ENR)差异显著。嗜酸性粒细胞计数、EMR 和 ENR 与疾病严重程度呈负相关。ENR是评估银屑病严重程度最可靠的嗜酸性粒细胞计数衍生标记物,其AUC为0.627,临界值为0.03。本研究首次在文献中评估了嗜酸性粒细胞计数衍生炎症标记物在评估疾病严重程度方面的作用,结果表明嗜酸性粒细胞计数、EMR和ENR都是可靠的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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