The connection between fatty acids and inflammation in celiac disease; a deep exploring.

IF 3.6 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Tissue Barriers Pub Date : 2024-04-15 DOI:10.1080/21688370.2024.2342619

Sajjad Bakhtiari, N. Asri, Mahtab Jahdkaran, Mostafa Rezaei-Tavirani, Somayeh Jahani-Sherafat, M. Rostami-Nejad

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Abstract

The interplay between fatty acids (FAs) and celiac disease (CD) is a burgeoning field of research with significant implications for understanding the pathophysiology and potential therapeutic avenues for this autoimmune disorder. CD, triggered by gluten consumption in susceptible individuals, presents with a range of intestinal and extra-intestinal symptoms impacting various bodily functions. The disruption of intestinal tight junctions (TJs) by gluten proteins leads to increased gut permeability and subsequent inflammatory responses mediated by T-cells. FAs, crucial components of cell membranes, play diverse roles in inflammation and immune regulation. In fact, FAs have been shown to modulate inflammatory processes through various mechanisms. Studies have highlighted alterations in FA profiles in individuals with CD, indicating potential implications for disease pathogenesis and micronutrient deficiencies. Moreover, the exploration of FAs as biomarkers for CD diagnosis offers promising avenues for future research and therapeutic interventions. Understanding the intricate relationship between FAs and CD could lead to novel approaches in managing this complex autoimmune disorder. Therefore, this review article aims to provide an overview of the connection between FAs and inflammation in CD.

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深入探讨乳糜泻中脂肪酸与炎症之间的联系。

脂肪酸（FAs）与乳糜泻（CD）之间的相互作用是一个新兴的研究领域，对了解这种自身免疫性疾病的病理生理学和潜在治疗途径具有重要意义。乳糜泻是由易感人群食用麸质引发的，会出现一系列肠道和肠道外症状，影响身体的各种功能。麸质蛋白对肠道紧密连接（TJ）的破坏会导致肠道通透性增加，继而引发由 T 细胞介导的炎症反应。FAs是细胞膜的重要组成部分，在炎症和免疫调节中发挥着多种作用。事实上，FAs 已被证明可通过各种机制调节炎症过程。研究强调了 CD 患者体内 FA 特征的改变，表明其对疾病发病机制和微量营养素缺乏具有潜在影响。此外，将脂肪酸作为诊断 CD 的生物标志物的探索为未来的研究和治疗干预提供了广阔的前景。了解 FAs 与 CD 之间错综复杂的关系可为治疗这种复杂的自身免疫性疾病提供新的方法。因此，本综述文章旨在概述 CD 中 FAs 与炎症之间的联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tissue Barriers MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

6.60

自引率

6.50%

发文量

期刊介绍： Tissue Barriers is the first international interdisciplinary journal that focuses on the architecture, biological roles and regulation of tissue barriers and intercellular junctions. We publish high quality peer-reviewed articles that cover a wide range of topics including structure and functions of the diverse and complex tissue barriers that occur across tissue and cell types, including the molecular composition and dynamics of polarized cell junctions and cell-cell interactions during normal homeostasis, injury and disease state. Tissue barrier formation in regenerative medicine and restoration of tissue and organ function is also of interest. Tissue Barriers publishes several categories of articles including: Original Research Papers, Short Communications, Technical Papers, Reviews, Perspectives and Commentaries, Hypothesis and Meeting Reports. Reviews and Perspectives/Commentaries will typically be invited. We also anticipate to publish special issues that are devoted to rapidly developing or controversial areas of research. Suggestions for topics are welcome. Tissue Barriers objectives: Promote interdisciplinary awareness and collaboration between researchers working with epithelial, epidermal and endothelial barriers and to build a broad and cohesive worldwide community of scientists interesting in this exciting field. Comprehend the enormous complexity of tissue barriers and map cross-talks and interactions between their different cellular and non-cellular components. Highlight the roles of tissue barrier dysfunctions in human diseases. Promote understanding and strategies for restoration of tissue barrier formation and function in regenerative medicine. Accelerate a search for pharmacological enhancers of tissue barriers as potential therapeutic agents. Understand and optimize drug delivery across epithelial and endothelial barriers.