Imaging-Assisted Antisense Oligonucleotide Delivery for Tumor-Targeted Gene Therapy

Hanwen Liao, Siyi Wang, Xiaoning Wang, David Zixiang Dai, Yan Zhang*, Chenghong Zhu* and Jinbo Li*, 
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引用次数: 0

Abstract

Antisense oligonucleotide (ASO) represents a class of practical tools for targeting undruggable oncogenes with several candidates currently undergoing clinical investigation. The advancement of antisense therapeutics necessitates comprehensive approaches for evaluating their efficacy and improving their accuracy. Molecular imaging techniques offer a qualitative and quantitative means to assess therapeutics at the molecular, cellular, and in vivo levels, as well as to elucidate biodistribution and pharmacokinetics. These capabilities play a pivotal role in enhancing therapeutic evaluation and efficiency. This review systematically explores the current landscape of ASO delivery by leveraging a synergistic combination of imaging techniques and delivery vehicles to enhance oligonucleotide distribution and accumulation at tumor sites and thereby optimizing therapeutic outcomes.

Abstract Image

成像辅助反义寡核苷酸递送用于肿瘤靶向基因疗法
反义寡核苷酸(ASO)是一类针对不可药用的癌基因的实用工具,目前有几种候选药物正在接受临床研究。反义疗法的发展需要全面的方法来评估其疗效并提高其准确性。分子成像技术提供了一种定性和定量的方法,可从分子、细胞和体内水平评估疗法,并阐明生物分布和药代动力学。这些功能在提高治疗评估和效率方面发挥着关键作用。本综述系统地探讨了 ASO 给药的现状,即利用成像技术和给药载体的协同组合来增强寡核苷酸在肿瘤部位的分布和积累,从而优化治疗效果。
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来源期刊
Chemical & Biomedical Imaging
Chemical & Biomedical Imaging 化学与生物成像-
CiteScore
1.00
自引率
0.00%
发文量
0
期刊介绍: Chemical & Biomedical Imaging is a peer-reviewed open access journal devoted to the publication of cutting-edge research papers on all aspects of chemical and biomedical imaging. This interdisciplinary field sits at the intersection of chemistry physics biology materials engineering and medicine. The journal aims to bring together researchers from across these disciplines to address cutting-edge challenges of fundamental research and applications.Topics of particular interest include but are not limited to:Imaging of processes and reactionsImaging of nanoscale microscale and mesoscale materialsImaging of biological interactions and interfacesSingle-molecule and cellular imagingWhole-organ and whole-body imagingMolecular imaging probes and contrast agentsBioluminescence chemiluminescence and electrochemiluminescence imagingNanophotonics and imagingChemical tools for new imaging modalitiesChemical and imaging techniques in diagnosis and therapyImaging-guided drug deliveryAI and machine learning assisted imaging
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