Recent trends in bone tissue engineering: a review of materials, methods, and structures.

IF 3.9 3区医学 Q2 ENGINEERING, BIOMEDICAL

Biomedical materials Pub Date : 2024-04-18 DOI:10.1088/1748-605X/ad407d

Armaghan Moghaddam, Mehran Bahrami, Motahareh Mirzadeh, Mehrdad Khatami, S. Simorgh, Mohammadreza Chimehrad, B. Kruppke, Zohre Bagher, Davood Mehrabani, Hossein Ali Khonakdar

引用次数: 0

Abstract

Bone tissue engineering provides the treatment possibility for segmental long bone defects that are currently an orthopedic dilemma. This review explains different strategies, from biological, material, and preparation points of view, such as using different stem cells, ceramics, and metals, and their corresponding properties for bone tissue engineering applications. In addition, factors such as porosity, surface chemistry, hydrophilicity and degradation behavior that affect scaffold success are introduced. Besides, the most widely used production methods that result in porous materials are discussed. Gene delivery and secretome-based therapies are also introduced as a new generation of therapies. This review outlines the positive results and important limitations remaining in the clinical application of novel bone tissue engineering materials and methods for segmental defects.

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骨组织工程的最新趋势：材料、方法和结构综述。

骨组织工程为治疗节段性长骨缺损提供了可能，而节段性长骨缺损目前是整形外科的一个难题。本综述从生物、材料和制备的角度解释了不同的策略，如使用不同的干细胞、陶瓷和金属，以及它们在骨组织工程应用中的相应特性。此外，还介绍了孔隙率、表面化学、亲水性和降解行为等影响支架成功与否的因素。此外，还讨论了最广泛使用的多孔材料生产方法。此外，还介绍了基因递送和基于分泌物的新一代疗法。本综述概述了新型骨组织工程材料和方法在节段性缺损临床应用中取得的积极成果和存在的重要局限。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical materials 工程技术-材料科学：生物材料

CiteScore

6.70

自引率

7.50%

发文量

294

审稿时长

3 months

期刊介绍： The goal of the journal is to publish original research findings and critical reviews that contribute to our knowledge about the composition, properties, and performance of materials for all applications relevant to human healthcare. Typical areas of interest include (but are not limited to): -Synthesis/characterization of biomedical materials- Nature-inspired synthesis/biomineralization of biomedical materials- In vitro/in vivo performance of biomedical materials- Biofabrication technologies/applications: 3D bioprinting, bioink development, bioassembly & biopatterning- Microfluidic systems (including disease models): fabrication, testing & translational applications- Tissue engineering/regenerative medicine- Interaction of molecules/cells with materials- Effects of biomaterials on stem cell behaviour- Growth factors/genes/cells incorporated into biomedical materials- Biophysical cues/biocompatibility pathways in biomedical materials performance- Clinical applications of biomedical materials for cell therapies in disease (cancer etc)- Nanomedicine, nanotoxicology and nanopathology- Pharmacokinetic considerations in drug delivery systems- Risks of contrast media in imaging systems- Biosafety aspects of gene delivery agents- Preclinical and clinical performance of implantable biomedical materials- Translational and regulatory matters