Investigating the Mechanism of Banxia Xiexin Decoction in Treating Gastritis and Diabetes Mellitus through Network Pharmacology and Molecular Docking Analysis

IF 0.3 Q4 PHARMACOLOGY & PHARMACY

Current Drug Therapy Pub Date : 2024-04-18 DOI:10.2174/0115748855287070240409061220

Yikuan Du, Xianhong Chi, Qianwen Chen, Yue Xiao, Zhendong Ma, Zhenjie Wang, Zhuoming Guo, Peng Chen, Zilin Chen, Mengting Zhang, Jinyan Guo, YuQi Zhou, Chun Yang

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引用次数: 0

Abstract

Banxia Xiexin decoration (BXD), a complex prescription in Traditional Chinese Medicine (TCM), clinically acts as a treatment for gastritis and diabetes while its mechanism of treatment remains unknown. This study aimed to explore the common mechanism of BXD in treating gastritis and diabetes based on network pharmacology and molecular docking technology. The seven Chinese herbal components and drug targets were collected from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) for gastritis and diabetes using GeneCards, DisGeNET, Comparative Toxicogenomics Database (CTD), and Online Mendelian Inheritance in Man (OMIM) databases. Common drug and disease targets were imported into the STRING data platform for protein-protein interaction (PPI) analysis, and Cytoscape 3.7.2 software for network topology analysis, and core targets were filtered. There were 124 components, 249 targets, 449 targets for gastritis, and 4005 targets for diabetes. After mapping, 83 BXD targets for gastritis and diabetes were obtained, and the targets with high correlation were STAT 3, JUN, TNF, IL-6, etc. More relevant targets were involved in the cancer pathway, AGE-RAGE signaling pathway of diabetic complications, fluid shear stress, and atherosclerosis pathway. This study preliminarily reveals that BXD may play a role in the treatment of gastritis and diabetes mellitus through multi-components, multi-targets, and multi-pathways, and proposes some potential "component-target-pathway" hypotheses in light of previous reports.

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通过网络药理学和分子对接分析研究半夏泻心汤治疗胃炎和糖尿病的机制

半夏泻心汤（BXD）是一种中药复方制剂，临床上主要用于治疗胃炎和糖尿病，但其治疗机制尚不清楚。本研究利用GeneCards、DisGeNET、比较毒物基因组学数据库（CTD）和OnlineMendelian Inheritance in Man（OMIM）数据库，从中药系统药理学数据库和分析平台（TCMSP）中收集了七种中药成分和药物靶点，并将其导入到中药系统药理学数据库和分析平台。经图谱分析，胃炎和糖尿病共有83个BXD靶点，相关性较高的靶点有STAT 3、JUN、TNF、IL-6等。本研究初步揭示了BXD可能通过多成分、多靶点、多通路在胃炎和糖尿病的治疗中发挥作用，并结合之前的报道提出了一些潜在的 "成分-靶点-通路 "假说。

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来源期刊

Current Drug Therapy PHARMACOLOGY & PHARMACY-

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Current Drug Therapy publishes frontier reviews of high quality on all the latest advances in drug therapy covering: new and existing drugs, therapies and medical devices. The journal is essential reading for all researchers and clinicians involved in drug therapy.