Initial Experience with a New Self-Expanding Open-Cell Stent System with Antithrombotic Hydrophilic Polymer Coating (pEGASUS Stent) in the Treatment of Wide-Necked Intracranial Aneurysms.

IF 1.2 Q4 CLINICAL NEUROLOGY
F. Boxberg, M. Al-Tibi, K. Schulz, Heinrich Lanfermann, M. Schlunz-Hendann, D. Grieb
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Abstract

PURPOSE We report our initial experience with endovascular embolization of intracranial aneurysms using this new self-expanding open-cell stent system (pEGASUS stent system) with the antithrombogenic hydrophilic polymer coating. MATERIALS AND METHODS We retrospectively reviewed all patients treated with stent-assisted coiling or the Woven EndoBridge device using the pEGASUS stent system between September 2022 and June 2023. Demographic, clinical, and angiographic data were analyzed as well as short-term follow-up, including procedural complication rates and aneurysmal occlusion rates using the Raymond-Roy occlusion classification (RROC). RESULTS Twelve patients with 12 wide-necked intracranial aneurysms were treated with the pEGASUS stent system, including 2 acutely ruptured aneurysms embolized in an emergency setting. The treated aneurysms were located at the anterior communicating artery (25.0%), the basilar artery (50.0%), the middle cerebral artery (16.7%), and the internal carotid artery (8.3%). All stents were deployed successfully. Immediate complete aneurysmal occlusion (RROC class I) was achieved in 83.3% (10/12) and near-complete occlusion (RROC II) in 16.7% (2/12). No periprocedural complications occurred in patients treated in the elective setting. A single case of intraoperative in-stent thrombus formation occurred during the treatment of an acutely ruptured basilar aneurysm and was resolved with intravenous Tirofiban. No other periprocedural complications occurred. Eleven out of 12 patients were available for follow up (mean 7.4 months). Complete aneurysmal occlusion without in-stent stenosis (ISS) was seen in 10 patients (90.9%). One patient (9.1%) showed aneurysmal reperfusion (RROC IIIb) with asymptomatic moderate ISS. CONCLUSION Our initial results demonstrate that the pEGASUS stent system appears to be a safe and effective device for stent assisted embolization of wide-necked intracranial aneurysms. More data is necessary to evaluate long-term follow-up.
新型抗血栓亲水聚合物涂层自膨胀开放细胞支架系统(pEGASUS 支架)治疗宽颈颅内动脉瘤的初步经验。
材料和方法 我们回顾性分析了 2022 年 9 月至 2023 年 6 月期间使用 pEGASUS 支架系统进行支架辅助卷绕或 Woven EndoBridge 装置治疗的所有患者。我们分析了人口统计学、临床和血管造影数据以及短期随访情况,包括手术并发症发生率和使用雷蒙德-罗伊闭塞分类法(Raymond-Roy occlusion classification,RROC)计算的动脉瘤闭塞率。结果12例颅内宽颈动脉瘤患者接受了pEGASUS支架系统治疗,其中包括2例急诊栓塞的急性破裂动脉瘤。接受治疗的动脉瘤分别位于前交通动脉(25.0%)、基底动脉(50.0%)、大脑中动脉(16.7%)和颈内动脉(8.3%)。所有支架均成功植入。83.3%(10/12)的动脉瘤立即完全闭塞(RROC I级),16.7%(2/12)的动脉瘤接近完全闭塞(RROC II级)。在择期手术中接受治疗的患者未出现围手术期并发症。在治疗急性破裂的基底动脉瘤时,有一例患者在术中形成支架内血栓,经静脉注射替罗非班后血栓得以溶解。没有发生其他围手术期并发症。12 名患者中有 11 名接受了随访(平均 7.4 个月)。10名患者(90.9%)出现动脉瘤完全闭塞,无支架内狭窄(ISS)。结论我们的初步结果表明,pEGASUS 支架系统似乎是一种安全有效的支架辅助栓塞颅内宽颈动脉瘤的设备。需要更多数据来评估长期随访情况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.80
自引率
0.00%
发文量
34
审稿时长
12 weeks
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