Effect of whole-body vibration stimulation on plasma soluble TNF receptors in elderly with sarcopenia: a randomized controlled trial

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-19 DOI:10.1590/1414-431X2024e13282

H. C. Almeida, Vanessa K S Lage, R. Taiar, J.M. Santos, F. A. D. Paula, A. Rapin, D. Sá-Caputo, M. Bernardo-Filho, A. Lacerda, V.A. Mendonça

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引用次数: 0

Abstract

Abstract Sarcopenia is a pathology resulting from a progressive and severe loss of muscle mass, strength, and function in the course of aging, which has deleterious consequences on quality of life. Among the most widespread studies on the issue are those focused on the effect of different types of physical exercise on patients with sarcopenia. This randomized controlled study aimed to compare the effects of a whole-body vibration exercise (WBV) session on the inflammatory parameters of non-sarcopenic (NSG, n=22) and sarcopenic elderly (SG, n=22). NSG and SG participants were randomly divided into two protocols: intervention (squat with WBV) and control (squat without WBV). After a one-week washout period, participants switched protocols, so that everyone performed both protocols. Body composition was assessed by dual-energy radiological absorptiometry (DXA) and function through the six-minute walk test (6MWD) and Short Physical Performance Battery (SPPB). Plasma soluble tumor necrosis factor receptors (sTNFR) were determined by enzyme-linked immunosorbent assay (ELISA) and measured before and immediately after each protocol. After exercise with WBV, there was an increase in sTNFR2 levels in the NSG (P<0.01; d=-0.69 (-1.30; -0.08) and SG (P<0.01, d=-0.95 (-1.57; -0.32) groups. In conclusion, an acute session of WBV influenced sTNFr2 levels, with sarcopenic individuals showing a greater effect. This suggested that WBV had a more pronounced impact on sTNFr2 in those with loss of muscle strength and/or physical performance. Additionally, WBV is gaining recognition as an efficient strategy for those with persistent health issues.

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全身振动刺激对患有肌肉疏松症的老年人血浆可溶性 TNF 受体的影响：随机对照试验

摘要肌肉疏松症是一种在衰老过程中肌肉质量、力量和功能逐渐严重丧失的病理现象，会对生活质量产生有害影响。有关这一问题的研究中，最广泛的是关于不同类型的体育锻炼对肌肉疏松症患者的影响的研究。这项随机对照研究旨在比较全身振动运动（WBV）对非肌肉疏松症老人（NSG，22 人）和肌肉疏松症老人（SG，22 人）炎症指标的影响。NSG和SG参与者被随机分为两种方案：干预方案（深蹲加WBV）和对照方案（深蹲不加WBV）。经过一周的缓冲期后，参与者交换方案，这样每个人都同时进行两种方案。身体成分通过双能放射吸收测定法（DXA）进行评估，功能通过六分钟步行测试（6MWD）和短期体能测试（SPPB）进行评估。血浆可溶性肿瘤坏死因子受体（sTNFR）通过酶联免疫吸附测定法（ELISA）进行测定，并在每个方案之前和之后立即进行测量。在进行 WBV 运动后，NSG 组（P<0.01；d=-0.69 (-1.30; -0.08)）和 SG 组（P<0.01，d=-0.95 (-1.57; -0.32)）的 sTNFR2 水平有所增加。总之，WBV 急性训练会影响 sTNFr2 水平，对肌肉疏松者的影响更大。这表明，WBV 对肌肉力量和/或体能丧失者的 sTNFr2 有更明显的影响。此外，人们逐渐认识到，对于那些有持续性健康问题的人来说，WBV 是一种有效的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.