Human papillomavirus and Epstein-Barr virus infection in benign thyroid lesions.

Yingying Lu, Runyu Zhao, Yi Zhang, Shuixian Huang, Xiaoping Chen
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Abstract

INTRODUCTION The objective was to investigate the correlation between Epstein-Barr virus (EBV) and human papillomavirus (HPV) infection in the development of benign thyroid lesions. MATERIAL AND METHODS 29 cases of Hashimoto's thyroiditis (HT), 133 cases of thyroid adenoma, and 34 cases of HT with thyroid adenoma paraffin embedded tissue samples were used for EBV and HPV quantitative detection. RESULTS None of the tissue samples carried HPV DNA. In HT tissue samples, the positive rate of EBV was 55.2% (16/29). In thyroid adenoma tissue samples, the positive rate was 37.6% (50/133). In HT combined with thyroid adenoma tissue samples, the positive rate of EBV was 67.6% (23/34). There was no correlation between EBV infection and clinical features such as age and gender. CONCLUSION The occurrence and development of benign thyroid lesions are closely related to EBV infection. HT combined with thyroid adenoma may be more susceptible to EBV infection than simple HT and thyroid adenoma, which provides a new idea for the diagnosis and treatment of benign thyroid lesions.
甲状腺良性病变中的人类乳头瘤病毒和 Epstein-Barr 病毒感染。
材料与方法 对29例桥本氏甲状腺炎(HT)、133例甲状腺腺瘤和34例HT合并甲状腺腺瘤石蜡包埋组织样本进行EBV和HPV定量检测。在 HT 组织样本中,EBV 阳性率为 55.2%(16/29)。在甲状腺腺瘤组织样本中,阳性率为 37.6%(50/133)。在甲状腺肿合并甲状腺激素组织样本中,EB病毒的阳性率为67.6%(23/34)。结论 甲状腺良性病变的发生和发展与 EBV 感染密切相关。HT合并甲状腺腺瘤可能比单纯HT合并甲状腺腺瘤更易感染EBV,这为甲状腺良性病变的诊断和治疗提供了新思路。
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