Verification of Source Activations in a 3D Brain Model Using ‘CLEVER’ Algorithm for Mental Arithmetic Conditions

Abstract

Background: Living conditions are becoming challenging day by day. Mental stress on individuals is increasing due to multiple reasons. As mental stress is a major cause of mental illness, it must be detected at the earliest to prevent serious conditions such as depression and anxiety. Purpose: The focus of this study is to detect the exact location of the source which causes such damage. In this article, we analyse the mental conditions of subjects under a workload of performing mental arithmetic calculations for various frequency bands and plot the topography to understand the areas of active potentials. Methods: We propose a Novel Cluster Ensemble Verifier (CLEVER) algorithm, which combines two different techniques: clustering and source localisation. The proposed algorithm is highly efficient in identifying the exact location of the source. It is seen that the topographic plots of the independent component analysis (ICA), which has the maximum percentage of relative variance, correlates to the cluster generated. We are able to give the percentage-wise contribution of every component which is responsible for brain source activation with less time complexity. Results: Out of 72 subjects, in 67 subjects, 299 out of 433 components originate from the occipital and parietal areas of the brain with a maximum power of 43.5 µv 2 . As an example, the relative variance of one component is found to be contributing up to 74.03% to source activations. Clusters show similarity across the subjects in the parietal and occipital areas of the brain. The dataset used for experimentation is EEGMAT from Physionet’s repository. The computation time for the algorithms is 17.6 ± 3.2 minutes. Conclusion: Findings show that during mental arithmetic calculations, both occipital and parietal areas of the brain are involved. As the data is acquired by orally mentioning the mathematical problem, subjects tend to visualise the numbers while finding the solution, which is reflected in the occipital area of the brain. CLEVER algorithm verifies the origin of the activity in the occipital and parietal areas of the brain.