Distinguishing bipolar depression, bipolar mania, and major depressive disorder by gut microbial characteristics

IF 5 2区医学 Q1 CLINICAL NEUROLOGY

Bipolar Disorders Pub Date : 2024-04-22 DOI:10.1111/bdi.13439

Taipeng Sun, Gang Chen, Wenhao Jiang, Wei Xu, Linlin You, Chenguang Jiang, Suzhen Chen, Dan Wang, Xiao Zheng, Yonggui Yuan

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引用次数: 0

Abstract

Background

Gut microbial disturbance has been widely confirmed in mood disorders. However, little is known about whether gut microbial characteristics can distinguish major depressive disorder (MDD), bipolar depression (BP-D), and bipolar mania (BP-M).

Methods

This was a prospective case–control study. The composition of gut microbiota was profiled using 16S ribosomal RNA (rRNA) gene sequencing of fecal samples and compared between healthy controls (HC; n = 46), MDD (n = 51), BP-D (n = 44), and patients with BP-M (n = 45).

Results

Gut microbial compositions were remarkably changed in the patients with MDD, BP-D, and BP-M. Compared to HC, distinct gut microbiome signatures were found in MDD, BP-D, and BP-M, and some gut microbial changes were overlapping between the three mood disorders. Furthermore, we identified a signature of 7 operational taxonomic units (OUT; Prevotellaceae-related OUT22, Prevotellaceae-related OUT31, Prevotellaceae-related OTU770, Ruminococcaceae-related OUT70, Bacteroidaceae-related OTU1536, Propionibacteriaceae-related OTU97, Acidaminococcaceae-related OTU34) that can distinguish patients with MDD from those with BP-D, BP-M, or HC, with area under the curve (AUC) values ranging from 0.910 to 0.996.

Conclusion

Our results provide the clinical rationale for the discriminative diagnosis of MDD, BP-D, and BP-M by characteristic gut microbial features.

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通过肠道微生物特征区分双相抑郁症、双相躁狂症和重度抑郁症。

背景肠道微生物紊乱已在情绪障碍中得到广泛证实。然而，人们对肠道微生物特征能否区分重度抑郁障碍（MDD）、双相抑郁（BP-D）和双相躁狂（BP-M）知之甚少。结果MDD、BP-D 和 BP-M 患者的肠道微生物组成发生了显著变化。与HC相比，在MDD、BP-D和BP-M患者中发现了不同的肠道微生物组特征，而且这三种情绪障碍之间的一些肠道微生物变化是重叠的。此外，我们还发现了一个由 7 个操作分类单元（OUT；前胡相关 OUT22、前胡相关 OUT31、前胡相关 OTU770、反刍球菌相关 OUT70、类杆菌相关 OTU1536、丙酸杆菌相关 OTU97、酸性球菌相关 OTU34）组成的特征，该特征可将 MDD 患者与 BP-D、BP-M 或 HC 患者区分开来，其曲线下面积（AUC）值从 0.910 到 0.996。结论我们的研究结果为通过肠道微生物特征对 MDD、BP-D 和 BP-M 进行鉴别诊断提供了临床依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bipolar Disorders 医学-精神病学

CiteScore

8.20

自引率

7.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Bipolar Disorders is an international journal that publishes all research of relevance for the basic mechanisms, clinical aspects, or treatment of bipolar disorders and related illnesses. It intends to provide a single international outlet for new research in this area and covers research in the following areas: biochemistry physiology neuropsychopharmacology neuroanatomy neuropathology genetics brain imaging epidemiology phenomenology clinical aspects and therapeutics of bipolar disorders Bipolar Disorders also contains papers that form the development of new therapeutic strategies for these disorders as well as papers on the topics of schizoaffective disorders, and depressive disorders as these can be cyclic disorders with areas of overlap with bipolar disorders. The journal will consider for publication submissions within the domain of: Perspectives, Research Articles, Correspondence, Clinical Corner, and Reflections. Within these there are a number of types of articles: invited editorials, debates, review articles, original articles, commentaries, letters to the editors, clinical conundrums, clinical curiosities, clinical care, and musings.