PET/CT in leukemia: utility and future directions.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-22 DOI:10.1097/MNM.0000000000001846

Akram Al-Ibraheem, Sudqi Allouzi, A. Abdlkadir, Miriam Mikhail-Lette, K. Al-rabi, M. Ma'koseh, Peter Knoll, Zaid Abdelrhman, Omar Shahin, Malik E. Juweid, Diana Paez, E. Lopci

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引用次数: 0

Abstract

2-Deoxy-2-[18F]fluoro-d-glucose PET/computed tomography ([18F]FDG PET/CT) has proven to be a sensitive method for the detection and evaluation of hematologic malignancies, especially lymphoma. The increasing incidence and mortality rates of leukemia have raised significant concerns. Through the utilization of whole-body imaging, [18F]FDG PET/CT provides a thorough assessment of the entire bone marrow, complementing the limited insights provided by biopsy samples. In this regard, [18F]FDG PET/CT has the ability to assess diverse types of leukemia The utilization of [18F]FDG PET/CT has been found to be effective in evaluating leukemia spread beyond the bone marrow, tracking disease relapse, identifying Richter's transformation, and assessing the inflammatory activity associated with acute graft versus host disease. However, its role in various clinical scenarios in leukemia remains unacknowledged. Despite their less common use, some novel PET/CT radiotracers are being researched for potential use in specific scenarios in leukemia patients. Therefore, the objectives of this review are to provide a thorough assessment of the current applications of [18F]FDG PET/CT in the staging and monitoring of leukemia patients, as well as the potential for an expanding role of PET/CT in leukemia patients.

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PET/CT 在白血病中的应用：实用性和未来方向。

2-Deoxy-2-[18F]fluoro-d-glucose PET/computed tomography（[18F]FDG PET/CT）已被证明是检测和评估血液系统恶性肿瘤，尤其是淋巴瘤的灵敏方法。白血病发病率和死亡率的上升引起了人们的极大关注。通过利用全身成像，[18F]FDG PET/CT 可对整个骨髓进行全面评估，补充活检样本提供的有限信息。在这方面，[18F]FDG PET/CT 能够评估各种类型的白血病。[18F]FDG PET/CT 在评估白血病向骨髓外扩散、跟踪疾病复发、识别里氏转化以及评估与急性移植物抗宿主疾病相关的炎症活动方面非常有效。然而，它在白血病各种临床情况中的作用仍未得到认可。尽管PET/CT放射性核素的使用并不普遍，但一些新型的PET/CT放射性核素正在被研究用于白血病患者的特定情况。因此，本综述的目的是全面评估[18F]FDG PET/CT 目前在白血病患者分期和监测中的应用，以及 PET/CT 在白血病患者中发挥更大作用的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.