What are the effects of pharmacological, non-invasive brain stimulation and psychological interventions, and their combination, in the treatment of post-stroke depression? A Cochrane Review summary with commentary

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-23 DOI:10.3233/nre-246003

E. Sen

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Abstract

BACKGROUND: Post-stroke depression (PSD) is a prevalent condition that can significantly influence the recovery process. OBJECTIVE: To assess the effects of pharmacological, non-invasive brain stimulation and psychological interventions, and their combination on PSD. METHODS: A summary of the Cochrane Review by Allida et al. (2023), with comments from a rehabilitation perspective. RESULTS: Sixty-one studies with 5831 participants were included in the Cochrane Review. Very low-certainty evidence indicated favorable treatment effects of pharmacological interventions, psychological therapies, and the combination of pharmacological intervention and non-invasive brain stimulation on PSD. Pharmacological intervention has resulted in increased side effects associated with the central nervous system and gastrointestinal system, with very low-certainty evidence. CONCLUSION: Evidence for the effectiveness of pharmacological, psychological, and combination therapies for the management of PSD is uncertain, as the quality of the evidence has been assessed as very low. Therefore, further studies with improved methods should investigate pharmacological and non-pharmacological interventions for the treatment of depression in stroke survivors.

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药物、非侵入性脑部刺激和心理干预及其组合治疗卒中后抑郁症的效果如何？带评论的科克伦综述摘要

背景：脑卒中后抑郁症（PSD）是一种普遍存在的疾病，会严重影响患者的康复进程。目的：评估药物、非侵入性脑刺激和心理干预及其组合对 PSD 的影响。方法：对 Allida 等人（2023 年）的 Cochrane 综述进行总结，并从康复的角度进行评论。结果：共有 61 项研究、5831 名参与者被纳入 Cochrane 综述。确定性极低的证据表明，药物干预、心理疗法以及药物干预与非侵入性脑部刺激相结合对 PSD 有良好的治疗效果。药物干预导致与中枢神经系统和胃肠道系统相关的副作用增加，其证据的确定性很低。结论：药物、心理和综合疗法对治疗 PSD 的有效性尚不确定，因为证据的质量被评估为非常低。因此，应采用改进的方法进一步研究治疗中风幸存者抑郁的药物和非药物干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.