Circadian regulation of cancer stem cells and the tumor microenvironment during metastasis

IF 23.5 1区医学 Q1 ONCOLOGY

Nature cancer Pub Date : 2024-04-23 DOI:10.1038/s43018-024-00759-4

Yu Wang, Rajesh Narasimamurthy, Meng Qu, Nuolin Shi, Haidong Guo, Yuezhen Xue, Nick Barker

引用次数: 0

Abstract

The circadian clock regulates daily rhythms of numerous physiological activities through tightly coordinated modulation of gene expression and biochemical functions. Circadian disruption is associated with enhanced tumor formation and metastasis via dysregulation of key biological processes and modulation of cancer stem cells (CSCs) and their specialized microenvironment. Here, we review how the circadian clock influences CSCs and their local tumor niches in the context of different stages of tumor metastasis. Identifying circadian therapeutic targets could facilitate the development of new treatments that leverage circadian modulation to ablate tumor-resident CSCs, inhibit tumor metastasis and enhance response to current therapies. Barker and colleagues discuss the interplay between circadian rhythm, the tumor microenvironment and stem cells and how these are linked to metastasis as well as how these interactions could be clinically relevant.

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癌症干细胞和肿瘤微环境在转移过程中的昼夜节律调控。

昼夜节律钟通过对基因表达和生化功能的紧密协调调控，调节着众多生理活动的日常节律。昼夜节律紊乱与肿瘤的形成和转移有关，其原因是关键生物过程失调以及癌症干细胞（CSCs）及其特化微环境的调节。在此，我们回顾了昼夜节律如何在肿瘤转移的不同阶段影响 CSCs 及其局部肿瘤壁龛。确定昼夜节律治疗靶点可以促进新疗法的开发，利用昼夜节律调节消减驻留在肿瘤中的CSCs、抑制肿瘤转移并增强对当前疗法的反应。巴克及其同事讨论了昼夜节律、肿瘤微环境和干细胞之间的相互作用，以及这些因素与转移的关系，以及这些相互作用如何与临床相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature cancer Medicine-Oncology

CiteScore

31.10

自引率

1.80%

发文量

129

期刊介绍： Cancer is a devastating disease responsible for millions of deaths worldwide. However, many of these deaths could be prevented with improved prevention and treatment strategies. To achieve this, it is crucial to focus on accurate diagnosis, effective treatment methods, and understanding the socioeconomic factors that influence cancer rates. Nature Cancer aims to serve as a unique platform for sharing the latest advancements in cancer research across various scientific fields, encompassing life sciences, physical sciences, applied sciences, and social sciences. The journal is particularly interested in fundamental research that enhances our understanding of tumor development and progression, as well as research that translates this knowledge into clinical applications through innovative diagnostic and therapeutic approaches. Additionally, Nature Cancer welcomes clinical studies that inform cancer diagnosis, treatment, and prevention, along with contributions exploring the societal impact of cancer on a global scale. In addition to publishing original research, Nature Cancer will feature Comments, Reviews, News & Views, Features, and Correspondence that hold significant value for the diverse field of cancer research.