Clinical conundrums in pediatric kidney transplantation: What we know about the role of angiotensin II type I receptor antibodies in pediatric kidney transplantation and the path forward.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-23 DOI:10.1111/petr.14762

Meghan H Pearl

引用次数: 0

Abstract

Antibodies to angiotensin II type 1 receptor (AT1R-Abs) are among the most well-studied non-HLA antibodies in renal transplantation. These antibodies have been shown to be common in pediatric kidney transplantation and associated with antibody-mediated rejection (AMR), vascular inflammation, development of human leukocyte donor-specific antibodies (HLA DSA), and allograft loss. As AT1R-Ab testing becomes more readily accessible, evidence to guide clinical practice for testing and treating AT1R-Ab positivity in pediatric kidney transplant recipients remains limited. This review discusses the clinical complexities of evaluating AT1R-Abs given the current available evidence.

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小儿肾移植的临床难题：我们对血管紧张素 II I 型受体抗体在小儿肾移植中的作用的认识和未来之路。

血管紧张素 II 1 型受体抗体（AT1R-Abs）是肾移植中研究最深入的非 HLA 抗体之一。这些抗体已被证明在小儿肾移植中很常见，并与抗体介导的排斥反应（AMR）、血管炎症、人类白细胞供体特异性抗体（HLA DSA）的产生和异体移植物丢失有关。随着AT1R-Ab检测越来越容易获得，指导临床实践检测和治疗小儿肾移植受者AT1R-Ab阳性的证据仍然有限。本综述讨论了根据现有证据评估 AT1R-Ab 的临床复杂性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.