Fabrication of a novel bone adhesive (crosslinked phytic acid-gelatin coordinated with magnesium phosphate and calcined dolomite, and montmorillonite) for enhancing adhesion strength and biocompatibility

Abstract

Bone adhesives are known as a promising fracture treatment material because they can quickly heal broken bones. However, the existing bone adhesives have the disadvantages of weak binding ability to bone tissue, non-absorption, or difficulty in curing under wet conditions, which limits their wide application in the field of bone tissue engineering. In this study, the raw material of magnesium phosphate bone adhesive was modified, and the composite material of magnesium phosphate bone repair was prepared by the method of solid–liquid blending crosslinking. Mineral-organic composite, a new type of bone adhesive was prepared using calcined dolomite and montmorillonite as mineral components, phytic acid and gelatin as organic components. The compressive strength, porosity and bonding strength of the magnesium phosphate-based bone adhesive were analyzed by Fourier transform infrared spectroscopy, X-ray diffraction and scanning electron microscopy. When the dosage of dolomite is 8 wt% and the concentration of gelatin is 9 wt%, the adhesion strength of the bone adhesive is 2.04 MPa after 168 h placement. And the compressive strength of the bone adhesive was 6.66 MPa after 168 h placement. After the prepared bone adhesives were immersed in SBF solution for 14 and 21 days, EDS analysis showed that the accumulated material was bone-like hydroxyapatite, indicating that the prepared bone adhesives had good osteogenic activity. In addition, it was also found that the bone adhesive had fluid absorption ability and no cytotoxicity. So, conclusively it can be stated that such newly synthesized bone adhesive has significant medical potential.