Long-range projections of oxytocin neurons in the marmoset brain

IF 3.3 4区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Arthur Lefevre, Jazlynn Meza, Cory T. Miller
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Abstract

The neurohormone oxytocin (OT) has become a major target for the development of novel therapeutic strategies to treat psychiatric disorders such as autism spectrum disorder because of its integral role in governing many facets of mammalian social behavior. Whereas extensive work in rodents has produced much of our knowledge of OT, we lack basic information about its neurobiology in primates making it difficult to interpret the limited effects that OT manipulations have had in human patients. In fact, previous studies have revealed only limited OT fibers in primate brains. Here, we investigated the OT connectome in marmoset using immunohistochemistry, and mapped OT fibers throughout the brains of adult male and female marmoset monkeys. We found extensive OT projections reaching limbic and cortical areas that are involved in the regulation of social behaviors, such as the amygdala, the medial prefrontal cortex, and the basal ganglia. The pattern of OT fibers observed in marmosets is notably similar to the OT connectomes described in rodents. Our findings here contrast with previous results by demonstrating a broad distribution of OT throughout the marmoset brain. Given the prevalence of this neurohormone in the primate brain, methods developed in rodents to manipulate endogenous OT are likely to be applicable in marmosets.

Abstract Image

狨猴脑中催产素神经元的长程投射。
神经激素催产素(OT)在哺乳动物社会行为的许多方面发挥着不可或缺的作用,因此已成为开发治疗自闭症谱系障碍等精神疾病的新型治疗策略的主要目标。虽然在啮齿类动物身上进行的大量研究使我们对 OT 有了更多的了解,但我们缺乏有关灵长类动物中 OT 神经生物学的基本信息,因此很难解释对人类患者进行 OT 操作所产生的有限影响。事实上,以往的研究仅发现灵长类动物大脑中有限的 OT 纤维。在这里,我们使用免疫组化方法研究了狨猴的 OT 连接组,并绘制了成年雄性和雌性狨猴大脑中的 OT 纤维图。我们发现广泛的OT投射到达边缘和皮层区域,这些区域参与调节社会行为,如杏仁核、内侧前额叶皮层和基底神经节。在狨猴身上观察到的OT纤维模式与在啮齿类动物身上观察到的OT连接体非常相似。我们的研究结果与之前的研究结果形成了鲜明对比,表明OT广泛分布于狨猴的整个大脑。鉴于这种神经激素在灵长类动物大脑中的普遍存在,在啮齿类动物中开发的操纵内源性OT的方法很可能也适用于狨猴。
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来源期刊
Journal of Neuroendocrinology
Journal of Neuroendocrinology 医学-内分泌学与代谢
CiteScore
6.40
自引率
6.20%
发文量
137
审稿时长
4-8 weeks
期刊介绍: Journal of Neuroendocrinology provides the principal international focus for the newest ideas in classical neuroendocrinology and its expanding interface with the regulation of behavioural, cognitive, developmental, degenerative and metabolic processes. Through the rapid publication of original manuscripts and provocative review articles, it provides essential reading for basic scientists and clinicians researching in this rapidly expanding field. In determining content, the primary considerations are excellence, relevance and novelty. While Journal of Neuroendocrinology reflects the broad scientific and clinical interests of the BSN membership, the editorial team, led by Professor Julian Mercer, ensures that the journal’s ethos, authorship, content and purpose are those expected of a leading international publication.
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