Association of individual and combined exposures of 10 metals with periodontitis: Results from a large population-based study

IF 3.4 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of periodontal research Pub Date : 2024-04-26 DOI:10.1111/jre.13270

Han Yang, Xiaoying Hu, Lan Luo, Shengjun Chen, Qinghui Ma, Yuezhen Liang, Yao Cheng, Zihao Ye, Baochang He, Jing Wang, Fa Chen

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引用次数: 0

Abstract

Aims

To systematically investigate the association between individual and combined metal exposure and periodontitis.

Methods

Data encompassing complete periodontal examinations and metal detection in blood and urine samples were procured from the National Health and Nutrition Examination Survey (NHANES) 2011–2014. Three statistical methods, namely weighted logistic regression, Bayesian kernel machine regression (BKMR), and weighted quantile sum (WQS) regression, were used to evaluate the independent and combined associations between metals and periodontitis.

Results

Elevated concentrations of blood cadmium (odds ratio [OR]: 1.73, 95% confidence interval [CI]: 1.15–2.61) and blood lead (OR: 1.17, 95 %CI: 1.02–1.34) exhibited a positive association with periodontitis, even after adjusting for potential confounding factors. The BKMR and WQS regression suggested that the co-exposure of metals was also positively associated with periodontitis. Moreover, estradiol and albumin were identified as potential mediators in the relationship between the WQS index of the 10 metals in blood and periodontitis explaining 25.36% and 2.02% of the relationship, respectively. Furthermore, generally consistent patterns of associations between metals and periodontitis and mediating roles of estrogen and albumin were observed after a series of sensitivity analyses.

Conclusion

This study provides evidence of positive associations between elevated levels of cadmium, lead or metal mixture and periodontitis, which may be partially mediated by sex hormones and oxidative stress indicators.

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10 种金属的个体暴露和综合暴露与牙周炎的关系：一项大型人群研究的结果。

方法从2011-2014年美国国家健康与营养调查（NHANES）中获取数据，包括完整的牙周检查和血液与尿液样本中的金属检测。采用加权逻辑回归、贝叶斯核机器回归（BKMR）和加权量化和回归（WQS）三种统计方法评估金属与牙周炎之间的独立和综合关联。结果即使调整了潜在的混杂因素，血镉浓度升高（几率比 [OR]：1.73，95% 置信区间 [CI]：1.15-2.61）和血铅浓度升高（几率比 [OR]：1.17，95% 置信区间 [CI]：1.02-1.34）仍与牙周炎呈正相关。BKMR 和 WQS 回归表明，共同暴露于金属也与牙周炎呈正相关。此外，在血液中 10 种金属的 WQS 指数与牙周炎的关系中，雌二醇和白蛋白被认为是潜在的中介因素，分别解释了 25.36% 和 2.02% 的关系。此外，经过一系列敏感性分析，还观察到金属与牙周炎之间的关联模式以及雌激素和白蛋白的中介作用基本一致。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of periodontal research 医学-牙科与口腔外科

CiteScore

6.90

自引率

5.70%

发文量

103

审稿时长

6-12 weeks

期刊介绍： The Journal of Periodontal Research is an international research periodical the purpose of which is to publish original clinical and basic investigations and review articles concerned with every aspect of periodontology and related sciences. Brief communications (1-3 journal pages) are also accepted and a special effort is made to ensure their rapid publication. Reports of scientific meetings in periodontology and related fields are also published. One volume of six issues is published annually.