Association Between Acquired Punctal Stenosis and Ocular Surface Disease: the Egg and the Chicken Story.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-04-26 DOI:10.1080/08820538.2024.2345279

Yael Lustig Barzelay, David Carmon, Mayan Dagan, Avishai Daniels, Daphna Landau-Prat, Guy J Ben Simon

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Abstract

PURPOSE This study explores the relationship between acquired punctal stenosis (PS) and ocular surface disease (OSD), assessing causal mechanisms and clinical impacts, utilizing a combination of a comprehensive literature review and a detailed analysis of a patient cohort from a tertiary care center. METHODS Data from 213 PS patients at Sheba Medical Center were retrospectively analyzed, evaluating various OSD symptoms and treatment effectiveness through standardized clinical assessments and statistical tests. RESULTS Predominantly older and female, many patients exhibited bilateral PS. OSD symptoms were found in 35.2% of all patients. Treatments like punctoplasty with stents significantly alleviated symptoms. Significant associations between treatment modalities and symptom improvement were identified. CONCLUSIONS PS and OSD have acomplex, bidirectional relationship that complicates treatment outcomes. This study underscores the need for thorough diagnostic approaches and personalized treatments to improve PS management. Further research is essential to deepen understanding of PS-OSD interactions and develop effective therapies.

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后天性眼球结膜狭窄与眼表疾病之间的关系：鸡蛋与鸡的故事。

目的本研究探讨了获得性穿刺狭窄（PS）与眼表疾病（OSD）之间的关系，通过综合文献综述和对一家三级医疗中心患者队列的详细分析，评估了成因机制和临床影响。方法回顾性分析了谢巴医疗中心 213 名 PS 患者的数据，通过标准化临床评估和统计测试评估了各种 OSD 症状和治疗效果。所有患者中有 35.2% 出现 OSD 症状。使用支架进行穿刺成形术等治疗可明显缓解症状。结论PS 和 OSD 具有复杂的双向关系，使治疗结果复杂化。这项研究强调，需要采用全面的诊断方法和个性化治疗来改善 PS 的管理。进一步的研究对于加深对 PS-OSD 相互作用的理解和开发有效疗法至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.