House of CarDs: Functional insights into the transcriptional regulator CdnL

IF 2.6 2区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Microbiology Pub Date : 2024-04-25 DOI:10.1111/mmi.15268

Erika L. Smith, Erin D. Goley

引用次数: 0

Abstract

Regulation of bacterial transcription is a complex and multi-faceted phenomenon that is critical for growth and adaptation. Proteins in the CarD_CdnL_TRCF family are widespread, often essential, regulators of transcription of genes required for growth and metabolic homeostasis. Research in the last decade has described the mechanistic and structural bases of CarD-CdnL-mediated regulation of transcription initiation. More recently, studies in a range of bacteria have begun to elucidate the physiological roles of CarD-CdnL proteins as well as mechanisms by which these proteins, themselves, are regulated. A theme has emerged wherein regulation of CarD-CdnL proteins is central to bacterial adaptation to stress and/or changing environmental conditions.

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CarDs 之家：转录调节因子 CdnL 的功能研究

细菌转录调控是一种复杂的多方面现象，对生长和适应至关重要。CarD_CdnL_TRCF 家族的蛋白质是生长和新陈代谢平衡所需的基因转录的广泛调控因子，通常也是必不可少的调控因子。过去十年的研究描述了 CarD-CdnL 介导的转录起始调控的机理和结构基础。最近，对一系列细菌的研究开始阐明 CarD-CdnL 蛋白的生理作用以及这些蛋白本身的调控机制。一个主题已经出现，即 CarD-CdnL 蛋白的调控是细菌适应压力和/或不断变化的环境条件的核心。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Microbiology 生物-生化与分子生物学

CiteScore

7.20

自引率

5.60%

发文量

132

审稿时长

1.7 months

期刊介绍： Molecular Microbiology, the leading primary journal in the microbial sciences, publishes molecular studies of Bacteria, Archaea, eukaryotic microorganisms, and their viruses. Research papers should lead to a deeper understanding of the molecular principles underlying basic physiological processes or mechanisms. Appropriate topics include gene expression and regulation, pathogenicity and virulence, physiology and metabolism, synthesis of macromolecules (proteins, nucleic acids, lipids, polysaccharides, etc), cell biology and subcellular organization, membrane biogenesis and function, traffic and transport, cell-cell communication and signalling pathways, evolution and gene transfer. Articles focused on host responses (cellular or immunological) to pathogens or on microbial ecology should be directed to our sister journals Cellular Microbiology and Environmental Microbiology, respectively.