Targeted therapy in ophthalmic oncology: The current status

IF 3.7 3区医学 Q1 OPHTHALMOLOGY

Asia-Pacific Journal of Ophthalmology Pub Date : 2024-03-01 DOI:10.1016/j.apjo.2024.100062

Mrittika Sen , Hakan Demirci , Santosh G. Honavar

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Abstract

There have been rapid advancements in the field of ocular oncology for the diagnosis and management of intraocular, adnexal, and orbital tumors. Targeted therapy is in the forefront of medical research in all fields including ocular oncology. Targeted therapy include drugs that target specific genetic mutations, pathways or proteins involved in the development of cancer. In contrast to traditionally used chemotherapy, drugs used in targeted therapy are highly specific for tumor cells and preserve the function of normal cells. This review aims to familiarize ophthalmologists with the drugs that are currently approved or undergoing clinical trials for use in ocular oncology. Targeted therapy is particularly useful for locally advanced or metastatic tumors, including but not limited to eyelid and periocular basal cell carcinoma, periocular cutaneous and conjunctival squamous cell carcinoma, ocular adnexal lymphoma, conjunctival melanoma, and uveal melanoma. The results are promising with improved survival outcomes and better tolerability than chemotherapeutic drugs.

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眼科肿瘤的靶向治疗：现状

眼部肿瘤学领域在诊断和治疗眼内、附件和眼眶肿瘤方面取得了突飞猛进的发展。在包括眼肿瘤学在内的所有领域，靶向治疗都处于医学研究的前沿。靶向治疗包括针对特定基因突变、途径或涉及癌症发展的蛋白质的药物。与传统的化疗相比，靶向治疗中使用的药物对肿瘤细胞具有高度特异性，并能保留正常细胞的功能。本综述旨在让眼科医生了解目前已获批准或正在进行临床试验的眼部肿瘤治疗药物。靶向治疗尤其适用于局部晚期或转移性肿瘤，包括但不限于眼睑和眼周基底细胞癌、眼周皮肤和结膜鳞状细胞癌、眼附属淋巴瘤、结膜黑色素瘤和葡萄膜黑色素瘤。与化疗药物相比，该疗法的生存率更高，耐受性更好，效果令人鼓舞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asia-Pacific Journal of Ophthalmology OPHTHALMOLOGY-

CiteScore

8.10

自引率

18.20%

发文量

197

审稿时长

6 weeks

期刊介绍： The Asia-Pacific Journal of Ophthalmology, a bimonthly, peer-reviewed online scientific publication, is an official publication of the Asia-Pacific Academy of Ophthalmology (APAO), a supranational organization which is committed to research, training, learning, publication and knowledge and skill transfers in ophthalmology and visual sciences. The Asia-Pacific Journal of Ophthalmology welcomes review articles on currently hot topics, original, previously unpublished manuscripts describing clinical investigations, clinical observations and clinically relevant laboratory investigations, as well as .perspectives containing personal viewpoints on topics with broad interests. Editorials are published by invitation only. Case reports are generally not considered. The Asia-Pacific Journal of Ophthalmology covers 16 subspecialties and is freely circulated among individual members of the APAO’s member societies, which amounts to a potential readership of over 50,000.