Irpexols A-C, xanthone derivatives from the endophyte fungus Irpex laceratus A878

IF 2.6 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2024-04-16 DOI:10.1016/j.fitote.2024.105952

Yuchan Chen , Nuoyi Wang , Weipeng Ma , Wei Gu , Zihuan Sang , Haibo Tan , Weimin Zhang , Hongxin Liu

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Abstract

Three new xanthone derivatives irpexols A-C (1–3) and five known xanthones including three dimeric ones were successfully isolated from Irpex laceratus A878, an endophytic fungus of the family Irpicaceae from the medicinal plant Pogostemon cablin (Blanco) Bentham (Lamiaceae). The structures of these compounds were elucidated by extensive spectroscopic analyses including ultraviolet-visible spectroscopy (UV), infrared spectroscopy (IR), mass spectrometry (MS), and nuclear magnetic resonance (NMR). All of the three new compounds (1–3) share a de-aromatic and highly‑oxygenated xanthone skeleton. In addition, the cytotoxic activity of compounds 1–8 were evaluated against SF-268, MCF-7, HepG2, and A549 tumor cell lines. The results revealed that compound 6 showed moderate cytotoxic activity with the IC₅₀ values ranging from 24.83 to 45.46 μM, while the IC₅₀ values of the positive control adriamycin was ranging from 1.11 to 1.44 μM.

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内生真菌 Irpex laceratus A878 的黄酮衍生物 Irpexols A-C

从药用植物 Pogostemon cablin (Blanco) Bentham（拉米亚西亚科）中成功地从 Irpicaceae 的内生真菌 Irpex laceratus A878 中分离出了三种新的氧杂蒽酮衍生物 irpexols A-C（1-3）和五种已知的氧杂蒽酮，其中包括三种二聚物。通过广泛的光谱分析，包括紫外可见光谱（UV）、红外光谱（IR）、质谱（MS）和核磁共振（NMR），阐明了这些化合物的结构。所有这三种新化合物（1-3）都有一个去芳香族和高氧的氧杂蒽酮骨架。此外，还评估了化合物 1-8 对 SF-268、MCF-7、HepG2 和 A549 肿瘤细胞系的细胞毒活性。结果表明，化合物 6 显示出中等程度的细胞毒性活性，其 IC50 值介于 24.83 到 45.46 μM 之间，而阳性对照阿霉素的 IC50 值介于 1.11 到 1.44 μM 之间。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.