A prospective cohort study of exposure to household pesticide with cardiovascular diseases mortality in older adults

IF 12.2 1区环境科学与生态学 Q1 ENGINEERING, ENVIRONMENTAL

Journal of Hazardous Materials Pub Date : 2024-04-21 DOI:10.1016/j.jhazmat.2024.134316

Xiyao Zhao , Jiayuan Li , Yongqi Liu , Yunjie Liu , Xia Jiang , Lu Long , Jintao Wang , Yuqing Yao , Qin Zhang , Ming Li , Xiaomeng Li , Ben Zhang , Jiaqiang Liao

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引用次数: 0

Abstract

Objectives

We examined the associations of self-reported exposures, and urinary metabolites related to household pesticide with cardiovascular disease (CVD) mortality in older adults based on the 2007 to 2014 waves of National Health and Nutrition Examination Survey (NHANES).

Methods

Information on application and urinary metabolites related to household pesticide exposure were collected. We estimated the risks of household pesticide exposure, urinary metabolites with subsequent incident CVD death using Cox proportional hazards regression models. The indirect effects of urinary metabolites and effect modifications were examined.

Results

The participants who reported exposure to household pesticide had a higher risk of incident CVD death (adjusted HR 1.40, 95% CI 1.08 to 1.81). Per 1-log10 increase in urinary N, N-diethyl-3-methylbenzamide (DEET) related to household insect repellents was associated with a higher risk of incident CVD death (adjusted HR 1.97, 95% CI 1.14 to 3.40). Urinary DEET explained 4.21% of the total association between household pesticide exposure and CVD death risk. The participants who persisted a low level of health diet exhibited pronounced CVD death risks with household pesticide exposures.

Conclusions

Exposure to household pesticide, especially household insect repellents, was consistently associated with an elevated CVD death risk in older adults. A heatlhy diet could partly attenuate the associations.

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关于接触家用杀虫剂与老年人心血管疾病死亡率的前瞻性队列研究

目的我们根据 2007 年至 2014 年的美国国家健康与营养调查（NHANES），研究了老年人自我报告的家庭杀虫剂暴露和泌尿代谢物与心血管疾病（CVD）死亡率的关系。方法我们收集了有关家庭杀虫剂暴露的应用和泌尿代谢物的信息。我们使用 Cox 比例危险度回归模型估算了家庭杀虫剂暴露、尿液代谢物与随后发生的心血管疾病死亡的风险。结果报告暴露于家庭杀虫剂的参与者发生心血管疾病死亡的风险较高（调整后 HR 1.40，95% CI 1.08 至 1.81）。与家用驱虫剂有关的尿液中N, N-二乙基-3-甲基苯甲酰胺（DEET）每增加1-log10，心血管疾病的死亡风险就会升高（调整后HR为1.97，95% CI为1.14-3.40）。尿液中的DEET占家庭杀虫剂暴露与心血管疾病死亡风险总关联的4.21%。结论暴露于家用杀虫剂，尤其是家用驱虫剂，与老年人心血管疾病死亡风险的升高一直相关。健康饮食可在一定程度上减轻这种关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Hazardous Materials 工程技术-工程：环境

CiteScore

25.40

自引率

5.90%

发文量

3059

审稿时长

58 days

期刊介绍： The Journal of Hazardous Materials serves as a global platform for promoting cutting-edge research in the field of Environmental Science and Engineering. Our publication features a wide range of articles, including full-length research papers, review articles, and perspectives, with the aim of enhancing our understanding of the dangers and risks associated with various materials concerning public health and the environment. It is important to note that the term "environmental contaminants" refers specifically to substances that pose hazardous effects through contamination, while excluding those that do not have such impacts on the environment or human health. Moreover, we emphasize the distinction between wastes and hazardous materials in order to provide further clarity on the scope of the journal. We have a keen interest in exploring specific compounds and microbial agents that have adverse effects on the environment.