Biobased short chain fatty acid production - Exploring microbial community dynamics and metabolic networks through kinetic and microbial modeling approaches

IF 12.1 1区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Merve Atasoy , William T. Scott Jr , Alberte Regueira , Miguel Mauricio-Iglesias , Peter J. Schaap , Hauke Smidt
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引用次数: 0

Abstract

In recent years, there has been growing interest in harnessing anaerobic digestion technology for resource recovery from waste streams. This approach has evolved beyond its traditional role in energy generation to encompass the production of valuable carboxylic acids, especially volatile fatty acids (VFAs) like acetic acid, propionic acid, and butyric acid. VFAs hold great potential for various industries and biobased applications due to their versatile properties. Despite increasing global demand, over 90% of VFAs are currently produced synthetically from petrochemicals. Realizing the potential of large-scale biobased VFA production from waste streams offers significant eco-friendly opportunities but comes with several key challenges. These include low VFA production yields, unstable acid compositions, complex and expensive purification methods, and post-processing needs. Among these, production yield and acid composition stand out as the most critical obstacles impacting economic viability and competitiveness. This paper seeks to offer a comprehensive view of combining complementary modeling approaches, including kinetic and microbial modeling, to understand the workings of microbial communities and metabolic pathways in VFA production, enhance production efficiency, and regulate acid profiles through the integration of omics and bioreactor data.

生物基短链脂肪酸生产--通过动力学和微生物建模方法探索微生物群落动力学和代谢网络
近年来,人们对利用厌氧消化技术从废物流中回收资源的兴趣与日俱增。这种方法已经超越了其在能源生产中的传统作用,开始生产有价值的羧酸,尤其是挥发性脂肪酸(VFAs),如乙酸、丙酸和丁酸。挥发性脂肪酸具有多种特性,因此在各种工业和生物基应用领域具有巨大潜力。尽管全球需求不断增长,但目前 90% 以上的 VFAs 都是通过石化合成生产的。实现从废物流中大规模生产生物基 VFA 的潜力提供了重要的生态友好机遇,但也面临着一些关键挑战。这些挑战包括 VFA 产率低、酸组成不稳定、纯化方法复杂且昂贵以及后处理需求。其中,产量和酸组成是影响经济可行性和竞争力的最关键障碍。本文试图提供一个综合视角,将动力学建模和微生物建模等互补建模方法结合起来,了解 VFA 生产过程中微生物群落和代谢途径的工作原理,通过整合全息数据和生物反应器数据提高生产效率并调节酸谱。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biotechnology advances
Biotechnology advances 工程技术-生物工程与应用微生物
CiteScore
25.50
自引率
2.50%
发文量
167
审稿时长
37 days
期刊介绍: Biotechnology Advances is a comprehensive review journal that covers all aspects of the multidisciplinary field of biotechnology. The journal focuses on biotechnology principles and their applications in various industries, agriculture, medicine, environmental concerns, and regulatory issues. It publishes authoritative articles that highlight current developments and future trends in the field of biotechnology. The journal invites submissions of manuscripts that are relevant and appropriate. It targets a wide audience, including scientists, engineers, students, instructors, researchers, practitioners, managers, governments, and other stakeholders in the field. Additionally, special issues are published based on selected presentations from recent relevant conferences in collaboration with the organizations hosting those conferences.
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