Difficulty sensitivity replaces reward sensitivity during adolescence: Task-related fMRI and functional connectivity during self-regulative learning choices

IF 3.4 Q2 NEUROSCIENCES
Esther H.H. Keulers , Luciana Falbo , Anique de Bruin , Peter L.J. Stiers
{"title":"Difficulty sensitivity replaces reward sensitivity during adolescence: Task-related fMRI and functional connectivity during self-regulative learning choices","authors":"Esther H.H. Keulers ,&nbsp;Luciana Falbo ,&nbsp;Anique de Bruin ,&nbsp;Peter L.J. Stiers","doi":"10.1016/j.tine.2024.100223","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim</h3><p>We examined age-related differences in valuation and cognitive control circuits during value-based decision-making.</p></div><div><h3>Methods</h3><p>13-year-olds (<em>N</em> = 25) and 17-year-olds (<em>N</em> = 22) made a metacognitive choice to be tested or not on an upcoming learning task, based on reward and difficulty associated with word-pairs. To investigate whether these determinants of subjective value are differently processed at different ages, we performed region-of-interest(ROI)-based analyses of task-related and functional connectivity data.</p><p>Results: We observed age-related differences in responsiveness of valuation structures (amygdala, ventral striatum, ventromedial prefrontal cortex) and caudate nucleus, with activity modulated by reward in 13-year-olds, while in 17-year-olds activity being responsive to difficulty. These accompanied age-related differences in functional connectivity between medial prefrontal and striatal/amygdala seeds.</p></div><div><h3>Discussion</h3><p>These results are in line with current views that sensitivity changes for reward and difficulty during adolescence are the result of a maturational switch in effort-related signalling in the cognitive control circuit, which increasingly regulates value-signalling structures.</p></div>","PeriodicalId":46228,"journal":{"name":"Trends in Neuroscience and Education","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2211949324000048/pdfft?md5=3532b8d65cce8b7223c281581d8bd9f3&pid=1-s2.0-S2211949324000048-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Neuroscience and Education","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2211949324000048","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Aim

We examined age-related differences in valuation and cognitive control circuits during value-based decision-making.

Methods

13-year-olds (N = 25) and 17-year-olds (N = 22) made a metacognitive choice to be tested or not on an upcoming learning task, based on reward and difficulty associated with word-pairs. To investigate whether these determinants of subjective value are differently processed at different ages, we performed region-of-interest(ROI)-based analyses of task-related and functional connectivity data.

Results: We observed age-related differences in responsiveness of valuation structures (amygdala, ventral striatum, ventromedial prefrontal cortex) and caudate nucleus, with activity modulated by reward in 13-year-olds, while in 17-year-olds activity being responsive to difficulty. These accompanied age-related differences in functional connectivity between medial prefrontal and striatal/amygdala seeds.

Discussion

These results are in line with current views that sensitivity changes for reward and difficulty during adolescence are the result of a maturational switch in effort-related signalling in the cognitive control circuit, which increasingly regulates value-signalling structures.

青春期对困难的敏感性取代了对奖励的敏感性自我调节学习选择过程中与任务相关的 fMRI 和功能连接
方法 13岁儿童(25人)和17岁儿童(22人)根据与词对相关的奖励和难度,在即将到来的学习任务中做出是否接受测试的元认知选择。为了研究这些主观价值的决定因素在不同年龄段是否有不同的处理方式,我们对任务相关数据和功能连接数据进行了基于兴趣区域(ROI)的分析:我们观察到估值结构(杏仁核、腹侧纹状体、腹外侧前额叶皮层)和尾状核的反应性存在与年龄相关的差异。这些结果与目前的观点一致,即青春期对奖赏和困难的敏感性变化是认知控制回路中与努力相关的信号成熟转换的结果,而认知控制回路越来越多地调节价值信号结构。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
6.30
自引率
6.10%
发文量
22
审稿时长
65 days
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信