Emerging concepts in alcohol, infection & immunity: A summary of the 2023 alcohol and immunology research interest group (AIRIG) meeting

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Alcohol Pub Date : 2024-04-04 DOI:10.1016/j.alcohol.2024.04.002

Lauren N. Rutt , Mengfei Liu , Esther Melamed , Shannon Twardy , Jamie L. Sturgill , Lisa A. Brenner , Josiah Hardesty , Steven A. Weinman , Madison M. Tschann , Jared Travers , David A. Welsh , Natalie Chichetto , Kathryn M. Crotty , Bryan Mackowiak , Samantha M. Yeligar , Todd A. Wyatt , Rachel H. McMahan , Mashkoor A. Choudry , Elizabeth J. Kovacs , Rebecca L. McCullough

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Abstract

On December 8th 2023, the annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held at the University of Colorado Anschutz Medical Campus in Aurora, Colorado. The 2023 meeting focused broadly on how acute and chronic alcohol exposure leads to immune dysregulation, and how this contributes to damage in multiple tissues and organs. These include impaired lung immunity, intestinal dysfunction, autoimmunity, the gut-Central Nervous System (CNS) axis, and end-organ damage. In addition, diverse areas of alcohol research covered multiple pathways behind alcohol-induced cellular dysfunction, including inflammasome activation, changes in miRNA expression, mitochondrial metabolism, gene regulation, and transcriptomics. Finally, the work presented at this meeting highlighted novel biomarkers and therapeutic interventions for patients suffering from alcohol-induced organ damage.

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酒精、感染与免疫的新概念：酒精与免疫学研究兴趣小组（AIRIG）2023 年会议摘要

2023 年 12 月 8 日，酒精与免疫学研究兴趣小组（AIRIG）年会在科罗拉多州奥罗拉市的科罗拉多大学安舒茨医学园区举行。2023 年会议广泛关注急性和慢性酒精暴露如何导致免疫失调，以及如何导致多个组织和器官受损。其中包括肺部免疫受损、肠道功能障碍、自身免疫、肠道-中枢神经系统（CNS）轴和内脏器官损伤。此外，酒精研究的不同领域涵盖了酒精诱导细胞功能障碍背后的多种途径，包括炎性体激活、miRNA表达变化、线粒体代谢、基因调控和转录组学。最后，本次会议上发表的研究成果强调了针对酒精诱发器官损伤患者的新型生物标志物和治疗干预措施。

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来源期刊

Alcohol 医学-毒理学

CiteScore

4.60

自引率

4.30%

发文量

审稿时长

15.6 weeks

期刊介绍： Alcohol is an international, peer-reviewed journal that is devoted to publishing multi-disciplinary biomedical research on all aspects of the actions or effects of alcohol on the nervous system or on other organ systems. Emphasis is given to studies into the causes and consequences of alcohol abuse and alcoholism, and biomedical aspects of diagnosis, etiology, treatment or prevention of alcohol-related health effects. Intended for both research scientists and practicing clinicians, the journal publishes original research on the neurobiological, neurobehavioral, and pathophysiological processes associated with alcohol drinking, alcohol abuse, alcohol-seeking behavior, tolerance, dependence, withdrawal, protracted abstinence, and relapse. In addition, the journal reports studies on the effects alcohol on brain mechanisms of neuroplasticity over the life span, biological factors associated with adolescent alcohol abuse, pharmacotherapeutic strategies in the treatment of alcoholism, biological and biochemical markers of alcohol abuse and alcoholism, pathological effects of uncontrolled drinking, biomedical and molecular factors in the effects on liver, immune system, and other organ systems, and biomedical aspects of fetal alcohol spectrum disorder including mechanisms of damage, diagnosis and early detection, treatment, and prevention. Articles are published from all levels of biomedical inquiry, including the following: molecular and cellular studies of alcohol''s actions in vitro and in vivo; animal model studies of genetic, pharmacological, behavioral, developmental or pathophysiological aspects of alcohol; human studies of genetic, behavioral, cognitive, neuroimaging, or pathological aspects of alcohol drinking; clinical studies of diagnosis (including dual diagnosis), treatment, prevention, and epidemiology. The journal will publish 9 issues per year; the accepted abbreviation for Alcohol for bibliographic citation is Alcohol.