Preparation of hydrogel using catechin-grafted chitosan and carboxymethyl cellulose

IF 2.8 4区工程技术 Q2 POLYMER SCIENCE

Macromolecular Research Pub Date : 2024-04-22 DOI:10.1007/s13233-024-00259-5

Sachiko Nitta, Sakura Taniguchi, Hiroyuki Iwamoto

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Abstract

Developing a novel approach for the administration of catechin that ensures sustained bioactivity, even at low doses, is crucial. In this regard, hydrogels were synthesized by polyion complexation of carboxymethyl cellulose (CMC) and chitosan (CS) grafted with epigallocatechin gallate (EGCG-g-CS), which can maintain enduring antioxidant activity. We initially synthesized grafted chitosan with various grafting ratios using a free-radical grafting method. Polyionic complexes were formed by ionic bonding of the amino groups in EGCG-g-CS with the carboxyl groups in CMC. After lyophilization, a hydrogel with a porous structure was obtained. Scanning electron microscopy (SEM), thermogravimetric differential thermal analysis (TG–DTA), and Fourier transform infrared (FT-IR) analyses of the gel structures were conducted. The swelling properties and porosity of the hydrogels were affected by the grafting ratio. The hydrogel gradually released EGCG under low pH conditions owing to chitosan solubilization, resulting in hydrogel disintegration. Additionally, the hydrogels demonstrated cell adhesion and viability. This study suggests that bio-based materials have potential as pH-dependent catechin-releasing materials.

Graphical Abstract

Preparation of hydrogel using catechin-grafted chitosan and carboxymethyl cellulose

Abstract Image

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使用儿茶素接枝壳聚糖和羧甲基纤维素制备水凝胶

开发一种新型的儿茶素给药方法至关重要，这种方法即使在低剂量时也能确保持续的生物活性。为此，我们通过羧甲基纤维素（CMC）和接枝了表没食子儿茶素没食子酸酯（EGCG-g-CS）的壳聚糖（CS）的多离子复合物合成了水凝胶，这种水凝胶可以保持持久的抗氧化活性。我们最初采用自由基接枝法合成了不同接枝比例的接枝壳聚糖。EGCG-g-CS 中的氨基与 CMC 中的羧基通过离子键结合形成多离子复合物。冻干后，得到了具有多孔结构的水凝胶。对凝胶结构进行了扫描电子显微镜（SEM）、热重差热分析（TG-DTA）和傅立叶变换红外光谱（FT-IR）分析。水凝胶的溶胀特性和孔隙率受接枝率的影响。由于壳聚糖的溶解作用，水凝胶在低 pH 条件下会逐渐释放出 EGCG，导致水凝胶崩解。此外，水凝胶还具有细胞粘附性和活力。这项研究表明，生物基材料具有作为依赖 pH 值的儿茶素释放材料的潜力。图文摘要利用儿茶素接枝壳聚糖和羧甲基纤维素制备水凝胶

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来源期刊

Macromolecular Research 工程技术-高分子科学

CiteScore

4.70

自引率

8.30%

发文量

100

审稿时长

1.3 months

期刊介绍： Original research on all aspects of polymer science, engineering and technology, including nanotechnology Presents original research articles on all aspects of polymer science, engineering and technology Coverage extends to such topics as nanotechnology, biotechnology and information technology The English-language journal of the Polymer Society of Korea Macromolecular Research is a scientific journal published monthly by the Polymer Society of Korea. Macromolecular Research publishes original researches on all aspects of polymer science, engineering, and technology as well as new emerging technologies using polymeric materials including nanotechnology, biotechnology, and information technology in forms of Articles, Communications, Notes, Reviews, and Feature articles.