RNA-mediated epigenetic regulation in exercised heart: Mechanisms and opportunities for intervention

IF 8.7 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Aspects of Medicine Pub Date : 2024-04-22 DOI:10.1016/j.mam.2024.101274

Lijun Wang , Wensi Wan , Shuang Zhang , Tarun Keswani , Guoping Li , Junjie Xiao

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引用次数: 0

Abstract

Physical exercise has been widely acknowledged as a beneficial lifestyle alteration and a potent non-pharmacological treatment for heart disease. Extensive investigations have revealed the beneficial effects of exercise on the heart and the underlying mechanisms involved. Exercise is considered one of the key factors that can lead to epigenetic alterations. The increasing number of identified molecules in the exercised heart has led to many studies in recent years that have explored the cellular function of ncRNAs and RNA modifications in the heart. Investigating the regulatory role of RNA-mediated epigenetic regulation in exercised hearts will contribute to the development of therapeutic strategies for the management of heart diseases. This review aims to summarize the positive impact of exercise on cardiac health. We will first provide an overview of the mechanisms through which exercise offers protection to the heart. Subsequently, we will delve into the current understanding of ncRNAs, specifically miRNAs, lncRNAs, and circRNAs, as well as RNA modification, focusing on RNA m⁶A and RNA A-to-I editing, and how they contribute to exercise-induced benefits for the heart. Lastly, we will explore the emerging therapeutic strategies that utilize exercise-mediated RNA epigenetic regulation in the treatment of heart diseases, while also addressing the challenges faced in this field.

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心脏运动中 RNA 介导的表观遗传调控：机制和干预机会

人们普遍认为，体育锻炼是一种有益的生活方式改变，也是治疗心脏病的一种有效的非药物疗法。广泛的研究揭示了运动对心脏的有益影响和相关的内在机制。运动被认为是导致表观遗传改变的关键因素之一。运动后心脏中被识别的分子越来越多，因此近年来有许多研究探讨了心脏中 ncRNA 和 RNA 修饰的细胞功能。研究 RNA 介导的表观遗传调控在运动性心脏中的调控作用，将有助于开发治疗策略来控制心脏疾病。本综述旨在总结运动对心脏健康的积极影响。首先，我们将概述运动保护心脏的机制。随后，我们将深入探讨目前对 ncRNA（特别是 miRNA、lncRNA 和 circRNA）以及 RNA 修饰（重点是 RNA m6A 和 RNA A 到 I 编辑）的理解，以及它们如何促进运动对心脏的益处。最后，我们将探讨利用运动介导的 RNA 表观遗传调控治疗心脏疾病的新兴治疗策略，同时探讨该领域面临的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Aspects of Medicine 医学-生化与分子生物学

CiteScore

18.20

自引率

0.00%

发文量

审稿时长

55 days

期刊介绍： Molecular Aspects of Medicine is a review journal that serves as an official publication of the International Union of Biochemistry and Molecular Biology. It caters to physicians and biomedical scientists and aims to bridge the gap between these two fields. The journal encourages practicing clinical scientists to contribute by providing extended reviews on the molecular aspects of a specific medical field. These articles are written in a way that appeals to both doctors who may struggle with basic science and basic scientists who may have limited awareness of clinical practice issues. The journal covers a wide range of medical topics to showcase the molecular insights gained from basic science and highlight the challenging problems that medicine presents to the scientific community.

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