Advances in the understanding and exploitation of carbohydrate-active enzymes

IF 6.9 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Rajneesh K. Bains , Seyed Amirhossein Nasseri , Jacob F. Wardman , Stephen G. Withers
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引用次数: 0

Abstract

Carbohydrate-active enzymes (CAZymes) are responsible for the biosynthesis, modification and degradation of all glycans in Nature. Advances in genomic and metagenomic methodologies, in conjunction with lower cost gene synthesis, have provided access to a steady stream of new CAZymes with both well-established and novel mechanisms. At the same time, increasing access to cryo-EM has resulted in exciting new structures, particularly of transmembrane glycosyltransferases of various sorts. This improved understanding has resulted in widespread progress in applications of CAZymes across diverse fields, including therapeutics, organ transplantation, foods, and biofuels. Herein, we highlight a few of the many important advances that have recently been made in the understanding and applications of CAZymes.

在了解和利用碳水化合物活性酶方面取得的进展
碳水化合物活性酶(CAZymes)负责自然界中所有聚糖的生物合成、修饰和降解。基因组学和元基因组学方法的进步,以及成本更低的基因合成技术,使人们可以源源不断地获得具有成熟和新颖机制的新 CAZymes。与此同时,冷冻电镜技术的日益普及也产生了令人兴奋的新结构,特别是各种跨膜糖基转移酶的结构。对CAZymes认识的提高使其在治疗、器官移植、食品和生物燃料等不同领域的应用取得了广泛进展。在此,我们将重点介绍最近在理解和应用 CAZymes 方面取得的许多重要进展中的几个。
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来源期刊
Current Opinion in Chemical Biology
Current Opinion in Chemical Biology 生物-生化与分子生物学
CiteScore
13.30
自引率
1.30%
发文量
113
审稿时长
74 days
期刊介绍: COCHBI (Current Opinion in Chemical Biology) is a systematic review journal designed to offer specialists a unique and educational platform. Its goal is to help professionals stay informed about the growing volume of information in the field of Chemical Biology through systematic reviews.
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