Is endocytosis by caveolae dependent on dynamin?

IF 81.3 1区生物学 Q1 CELL BIOLOGY

Nature Reviews Molecular Cell Biology Pub Date : 2024-04-22 DOI:10.1038/s41580-024-00735-x

Robert G. Parton, Justin W. Taraska, Richard Lundmark

引用次数: 0

Abstract

The large GTPase dynamin has a crucial role in endocytosis, working at the neck of clathrin-coated pits to drive vesicular scission. Until recently, dynamin was believed to regulate endocytosis through caveolae in a similar fashion. However, recent work calls for a serious reassessment of the role of dynamin in endocytosis by caveolae. Robert Parton and colleagues discuss novel evidence on the role of dynamin in caveolar endocytosis, which calls into question established models of dynamin-mediated fission.

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洞穴小体的内吞作用依赖于达纳明吗？

大 GTP 酶达因明在内吞中起着至关重要的作用，它在凝集素包被的凹坑颈部发挥作用，驱动囊泡裂解。直到最近，人们还认为达纳明以类似的方式通过洞穴调节内吞作用。然而，最近的研究要求对达明敏在洞穴内吞中的作用进行认真的重新评估。罗伯特-帕顿及其同事讨论了有关达赖素在洞穴内吞中作用的新证据，这些证据对达赖素介导的裂变的既定模型提出了质疑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Molecular Cell Biology 生物-细胞生物学

CiteScore

173.60

自引率

0.50%

发文量

118

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Molecular Cell Biology is a prestigious journal that aims to be the primary source of reviews and commentaries for the scientific communities it serves. The journal strives to publish articles that are authoritative, accessible, and enriched with easily understandable figures, tables, and other display items. The goal is to provide an unparalleled service to authors, referees, and readers, and the journal works diligently to maximize the usefulness and impact of each article. Nature Reviews Molecular Cell Biology publishes a variety of article types, including Reviews, Perspectives, Comments, and Research Highlights, all of which are relevant to molecular and cell biologists. The journal's broad scope ensures that the articles it publishes reach the widest possible audience.